HitPredict

Interactor 1: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Interactor 2: HMGB2 (P26583)
High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Gene: HMGB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0032496 - response to lipopolysaccharide GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 821 Hs			1 209
+	Hs
		601495 FGFR2_HUMAN (1-821): 0: 863: 100.00		TFAM_HUMAN (9-190): 7.47e-31: 114: 21.68
+	Hs
		601504 FGFR2_HUMAN (1-821): 0: 863: 100.00		SSRP1_HUMAN (5-84): 2.82e-09: 57.9: 35.00
+	Hs
		665580 EPHB2_HUMAN (9-766): 1.95e-166: 511: 17.58		TFAM_HUMAN (9-190): 7.47e-31: 114: 21.68
+	Hs
		674397 UFO_HUMAN (5-818): 3.59e-160: 490: 22.49		TFAM_HUMAN (9-190): 7.47e-31: 114: 21.68
+	Hs
		665210 EPHA2_HUMAN (18-798): 4.64e-157: 485: 19.21		TFAM_HUMAN (9-190): 7.47e-31: 114: 21.68
+	Hs
		958881 ROR2_HUMAN (11-820): 1.91e-156: 482: 20.29		TFAM_HUMAN (9-190): 7.47e-31: 114: 21.68
+	Hs
		384138 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21
+	Hs
		313694 ROR2_HUMAN (11-820): 1.91e-156: 482: 20.29		SOX14_HUMAN (3-94): 1.24e-25: 101: 19.57
+	Hs
		384301 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		HMGB2_HUMAN (1-187): 3.05e-41: 140: 100.00
+	Hs
		818072 EPHA7_HUMAN (64-791): 2.59e-157: 486: 19.23		SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83
+	Hs
		972320 TIE2_HUMAN (7-763): 1.63e-155: 485: 22.83		SSRP1_HUMAN (5-84): 2.82e-09: 57.9: 35.00
+	Hs
		385375 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		CIC_HUMAN (3-100): 1.66e-11: 64.7: 22.45
+	Hs
		384221 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		UBF1_HUMAN (10-158): 1.47e-09: 58.9: 24.72
+	Hs
		384722 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		SSRP1_HUMAN (5-84): 2.82e-09: 57.9: 35.00
+	Hs
		572621 VGFR1_HUMAN (5-134): 1.03e-11: 70.9: 16.42		TFAM_HUMAN (9-190): 7.47e-31: 114: 21.68