HitPredict

Interactor 1: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	19953087
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane and 1 others more... GO:0005938 - cell cortex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 821 Hs			1 1319
+	Hs
		507904 FGFR1_HUMAN (1-820): 0: 772: 71.17		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		609205 FGFR3_HUMAN (10-821): 0: 731: 65.69		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808060 EPHA5_HUMAN (18-766): 3.48e-163: 502: 17.53		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		434157 RET_HUMAN (228-816): 2.74e-144: 455: 34.26		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		384459 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		729242 VGFR3_HUMAN (42-385): 5.85e-18: 91.4: 17.62		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		572597 VGFR1_HUMAN (5-134): 1.03e-11: 70.9: 16.42		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		385368 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		385087 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Hs
		601595 FGFR2_HUMAN (1-821): 0: 863: 100.00		SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82
+	Mm
		601625 FGFR2_MOUSE (1-821): 0: 834: 96.96		SMUF1_MOUSE (539-719): 1.75e-21: 103: 18.65
+	Hs
		738232 FLT3_HUMAN (342-800): 5.44e-85: 293: 36.15		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Mm
		1206824 PTK7_MOUSE (163-379): 2.55e-18: 92.5: 19.20		HECW1_MOUSE (480-1317): 0: 712: 31.07
+	Hs
		674522 UFO_HUMAN (5-818): 3.59e-160: 490: 22.49		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		125077 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Dr
		1109027 FGR1A_DANRE (11-254): 8.53e-20: 96.7: 15.97		Q3KRP0_DANRE (404-835): 1.68e-24: 113: 13.92