Protein: S53A1
Solute carrier family 53 member 1 (Phosphate exporter SLC53A1) (Protein SYG1 homolog) (Xenotropic and polytropic murine leukemia virus receptor X3) (X-receptor) (Xenotropic and polytropic retrovirus receptor 1)

Gene: S53A1, XPR1
Organism: Homo sapiens
Interactions: 215
UniProt ID: Q9UBH6

Gene Ontology (top 5):
GO:0000822 - inositol hexakisphosphate binding
GO:0001618 - virus receptor activity
GO:0005315 - phosphate transmembrane transporter activity
GO:0005886 - plasma membrane
GO:0006817 - phosphate ion transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

641276

FGFR2
Fibroblast growth factor receptor 2

3

2

High-throughput

0.667

High

218905

TGON2
Trans-Golgi network integral membrane protein 2

3

0

High-throughput

0.638

High

771259

APJ
Apelin receptor

2

1

High-throughput

0.628

High

845544

PI2R
Prostacyclin receptor

2

1

High-throughput

0.628

High

1395979

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.618

High

761306

RYK
Tyrosine-protein kinase RYK

2

3

High-throughput

0.611

High

1458413

VSIG4
V-set and immunoglobulin domain-containing protein 4

3

1

High-throughput

0.609

High

420053

B3A2
Anion exchange protein 2

2

0

High-throughput

0.602

High

622699

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

0

High-throughput

0.602

High

821779

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.602

High

854593

S15A1
Solute carrier family 15 member 1

2

0

High-throughput

0.602

High

1142536

PDCD1
Programmed cell death protein 1

2

0

High-throughput

0.602

High

862725

UTRN
Utrophin

2

2

High-throughput

0.601

High

376051

RASK
GTPase KRas

2

2

High-throughput

0.584

High

978373

RHOB
Rho-related GTP-binding protein RhoB

2

9

High-throughput

0.584

High

1293928

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

2

High-throughput

0.574

High

1312295

MIRO2
Mitochondrial Rho GTPase 2

2

12

High-throughput

0.574

High

299413

FLOT1
Flotillin-1

2

1

High-throughput

0.571

High

750016

KINH
Kinesin-1 heavy chain

2

1

High-throughput

0.549

High

226246

STX6
Syntaxin-6

2

0

High-throughput

0.547

High

397128

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

182816

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.536

High

901645

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.536

High

914364

EFNA4
Ephrin-A4

1

1

High-throughput

0.536

High

1153453

CD226
CD226 antigen

1

2

High-throughput

0.536

High

1403986

SCN2A
Sodium channel protein type 2 subunit alpha

1

1

High-throughput

0.536

High

1407312

CML1
Chemerin-like receptor 1

1

1

High-throughput

0.536

High

132672

UPK1A
Uroplakin-1a

1

0

High-throughput

0.513

High

248516

O10H2
Olfactory receptor 10H2

1

0

High-throughput

0.513

High

467639

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.513

High

595118

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

0

High-throughput

0.513

High

596542

CTLA4
Cytotoxic T-lymphocyte protein 4

1

0

High-throughput

0.513

High

880212

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.513

High

901082

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.513

High

1026260

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.513

High

1203820

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1249516

VSTM1
V-set and transmembrane domain-containing protein 1

1

0

High-throughput

0.513

High

1399070

TMM74
Transmembrane protein 74

1

0

High-throughput

0.513

High

1432441

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1453095

NLGN3
Neuroligin-3

1

0

High-throughput

0.513

High

1453822

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.513

High

1458419

BACE2
Beta-secretase 2

1

0

High-throughput

0.513

High

171776

GAK
Cyclin-G-associated kinase

1

1

High-throughput

0.489

High

1458416

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.489

High

126853

RHOD
Rho-related GTP-binding protein RhoD

1

11

High-throughput

0.479

High

189901

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

374254

RASN
GTPase NRas

1

2

High-throughput

0.479

High

412745

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

440235

LCK
Tyrosine-protein kinase Lck

1

1

High-throughput

0.479

High

463815

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.479

High

466508

RHOC
Rho-related GTP-binding protein RhoC

1

7

High-throughput

0.479

High

540728

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

562462

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

581352

RAC2
Ras-related C3 botulinum toxin substrate 2

1

7

High-throughput

0.479

High

601478

RHOQ
Rho-related GTP-binding protein RhoQ

1

9

High-throughput

0.479

High

684040

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

2

High-throughput

0.479

High

710540

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.479

High

910239

RND2
Rho-related GTP-binding protein RhoN

1

11

High-throughput

0.479

High

953732

RAC3
Ras-related C3 botulinum toxin substrate 3

1

8

High-throughput

0.479

High

955713

CDC42
Cell division control protein 42 homolog

1

9

High-throughput

0.479

High

962592

RHOA
Transforming protein RhoA

1

8

High-throughput

0.479

High

962848

RND3
Rho-related GTP-binding protein RhoE

1

12

High-throughput

0.479

High

988788

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.479

High

1015876

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.479

High

1087328

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1151914

RHOH
Rho-related GTP-binding protein RhoH

1

9

High-throughput

0.479

High

1159551

NTRK2
BDNF/NT-3 growth factors receptor

1

4

High-throughput

0.479

High

1271030

RHOU
Rho-related GTP-binding protein RhoU

1

10

High-throughput

0.479

High

1366900

RND1
Rho-related GTP-binding protein Rho6

1

12

High-throughput

0.479

High

1396650

RHOV
Rho-related GTP-binding protein RhoV

1

9

High-throughput

0.479

High

1432990

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

1433558

RHOJ
Rho-related GTP-binding protein RhoJ

1

9

High-throughput

0.479

High

1438218

RHOF
Rho-related GTP-binding protein RhoF

1

10

High-throughput

0.479

High

1458409

ALK
ALK tyrosine kinase receptor

1

3

High-throughput

0.479

High

1458411

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

341159

DIRA3
GTP-binding protein Di-Ras3

1

0

High-throughput

0.458

High

845839

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.458

High

936473

AFAD
Afadin

1

0

High-throughput

0.458

High

1145149

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.458

High

1159890

OCLN
Occludin

1

0

High-throughput

0.458

High

1197116

AMOT
Angiomotin

1

0

High-throughput

0.458

High

1323029

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.458

High

262446

DTNB
Dystrobrevin beta

1

3

High-throughput

0.445

High

278576

VAMP4
Vesicle-associated membrane protein 4

1

5

High-throughput

0.445

High

344819

AP2A1
AP-2 complex subunit alpha-1

1

1

High-throughput

0.445

High

547496

DMD
Dystrophin

1

2

High-throughput

0.445

High

684421

DDX6
Probable ATP-dependent RNA helicase DDX6

1

2

High-throughput

0.445

High

692276

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

3

High-throughput

0.445

High

800586

VATA
V-type proton ATPase catalytic subunit A

1

5

High-throughput

0.445

High

914499

EFNB2
Ephrin-B2

1

1

High-throughput

0.445

High

998083

CSK21
Casein kinase II subunit alpha

1

2

High-throughput

0.445

High

1039998

AKA12
A-kinase anchor protein 12

1

1

High-throughput

0.445

High

1104888

SNTB2
Beta-2-syntrophin

1

1

High-throughput

0.445

High

1118461

SNTB1
Beta-1-syntrophin

1

1

High-throughput

0.445

High

1119345

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

1124936

FLOT2
Flotillin-2

1

1

High-throughput

0.445

High

1150497

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

1

High-throughput

0.445

High

1346817

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

8

High-throughput

0.445

High

1350779

TRPM4
Transient receptor potential cation channel subfamily M member 4

1

2

High-throughput

0.445

High

1353733

MOT10
Monocarboxylate transporter 10

1

1

High-throughput

0.445

High

1371982

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

6

High-throughput

0.445

High

1401032

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

6

High-throughput

0.445

High

1429714

KLC2
Kinesin light chain 2

1

2

High-throughput

0.445

High

1439292

E41L5
Band 4.1-like protein 5

1

2

High-throughput

0.445

High

1458418

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

6

High-throughput

0.445

High

291577

NU155
Nuclear pore complex protein Nup155

1

6

High-throughput

0.437

High

1252273

SYNE3
Nesprin-3

1

2

High-throughput

0.437

High

1396845

SNX27
Sorting nexin-27

1

1

High-throughput

0.437

High

1439413

E41LA
Band 4.1-like protein 4A

1

2

High-throughput

0.437

High

1458403

DNJ5B
DnaJ homolog subfamily C member 5B

1

1

High-throughput

0.437

High

136991

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.426

High

208579

PJA2
E3 ubiquitin-protein ligase Praja-2

1

0

High-throughput

0.426

High

228519

LANC1
Glutathione S-transferase LANCL1

1

0

High-throughput

0.426

High

255261

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

283723

GPC4
Glypican-4

1

0

High-throughput

0.426

High

343093

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.426

High

548629

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.426

High

921821

COPB
Coatomer subunit beta

1

0

High-throughput

0.426

High

1129928

KANK1
KN motif and ankyrin repeat domain-containing protein 1

1

0

High-throughput

0.426

High

1219631

DEN4C
DENN domain-containing protein 4C

1

0

High-throughput

0.426

High

1224715

TSH3
Teashirt homolog 3

1

0

High-throughput

0.426

High

1233545

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.426

High

1286722

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.426

High

1316124

K319L
Dyslexia-associated protein KIAA0319-like protein

1

0

High-throughput

0.426

High

1333511

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.426

High

1346660

VANG1
Vang-like protein 1

1

0

High-throughput

0.426

High

1370029

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.426

High

1386228

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

1400169

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

1436006

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.426

High

1439719

JPH1
Junctophilin-1

1

0

High-throughput

0.426

High

1450321

CC50A
Cell cycle control protein 50A

1

0

High-throughput

0.426

High

1458407

MTUS1
Microtubule-associated tumor suppressor 1

1

0

High-throughput

0.426

High

1458414

AT8A1
Phospholipid-transporting ATPase IA

1

0

High-throughput

0.426

High

230127

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

High-throughput

0.407

High

244192

KIF5C
Kinesin heavy chain isoform 5C

1

1

High-throughput

0.407

High

674359

BRD2
Bromodomain-containing protein 2

1

1

High-throughput

0.407

High

773676

COPB2
Coatomer subunit beta'

1

2

High-throughput

0.407

High

922070

COPA
Coatomer subunit alpha

1

2

High-throughput

0.407

High

935230

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.407

High

1060583

KLC1
Kinesin light chain 1

1

2

High-throughput

0.407

High

1097913

STX5
Syntaxin-5

1

3

High-throughput

0.407

High

1115473

CUL4B
Cullin-4B

1

1

High-throughput

0.407

High

1146654

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.407

High

1215377

DCAF8
DDB1- and CUL4-associated factor 8

1

1

High-throughput

0.407

High

1281277

TMED4
Transmembrane emp24 domain-containing protein 4

1

2

High-throughput

0.407

High

1389470

DAZP1
DAZ-associated protein 1

1

1

High-throughput

0.407

High

1393328

SAHH3
Adenosylhomocysteinase 3

1

1

High-throughput

0.407

High

1395153

DCAF5
DDB1- and CUL4-associated factor 5

1

1

High-throughput

0.407

High

1447904

SAR1A
Small COPII coat GTPase SAR1A

1

1

High-throughput

0.407

High

1449427

KLC4
Kinesin light chain 4

1

2

High-throughput

0.407

High

1458350

COPG2
Coatomer subunit gamma-2

1

1

High-throughput

0.407

High

1458404

DDX20
Probable ATP-dependent RNA helicase DDX20

1

3

High-throughput

0.407

High

1458417

TMED3
Transmembrane emp24 domain-containing protein 3

1

2

High-throughput

0.407

High

1186241

CEA21
Cell adhesion molecule CEACAM21

3

0

High-throughput

0.347

High

1386401

FAF2
FAS-associated factor 2

3

0

High-throughput

0.347

High

1458408

KDIS
Kinase D-interacting substrate of 220 kDa

3

0

High-throughput

0.345

High

219388

B4GA1
Beta-1,4-glucuronyltransferase 1

2

0

High-throughput

0.328

High

1252087

RN19B
E3 ubiquitin-protein ligase RNF19B

2

0

High-throughput

0.328

High

1458405

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

1237893

MYORG
Myogenesis-regulating glycosidase

2

0

High-throughput

0.313

High

71259

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

848584

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.279

Low

1022491

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.279

Low

1160785

DREB
Drebrin

1

0

High-throughput

0.279

Low

1383497

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.279

Low

1454012

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

1458420

TACC3
Transforming acidic coiled-coil-containing protein 3

1

0

High-throughput

0.279

Low

140019

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

327488

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

1187592

AR13B
ADP-ribosylation factor-like protein 13B

1

0

High-throughput

0.249

Low

1197735

MIDN
Midnolin

1

0

High-throughput

0.249

Low

1255925

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1381989

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

136561

GOLI4
Golgi integral membrane protein 4

1

0

High-throughput

0.232

Low

141153

NOP56
Nucleolar protein 56

1

0

High-throughput

0.232

Low

186445

TM9S1
Transmembrane 9 superfamily member 1

1

0

High-throughput

0.232

Low

239243

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.232

Low

244026

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

High-throughput

0.232

Low

251668

CCNT1
Cyclin-T1

1

0

High-throughput

0.232

Low

593708

BGAL
Beta-galactosidase

1

0

High-throughput

0.232

Low

755430

MA1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

1

0

High-throughput

0.232

Low

839928

AF9
Protein AF-9

1

0

High-throughput

0.232

Low

873345

COPD
Coatomer subunit delta

1

0

High-throughput

0.232

Low

946600

EVA1C
Protein eva-1 homolog C

1

0

High-throughput

0.232

Low

995323

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.232

Low

1105107

TCOF
Treacle protein

1

0

High-throughput

0.232

Low

1126281

GALT3
Polypeptide N-acetylgalactosaminyltransferase 3

1

0

High-throughput

0.232

Low

1134561

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

0

High-throughput

0.232

Low

1136402

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.232

Low

1139860

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.232

Low

1145417

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.232

Low

1150640

TSN
Translin

1

0

High-throughput

0.232

Low

1198091

FA98B
Protein FAM98B

1

0

High-throughput

0.232

Low

1204600

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

0

High-throughput

0.232

Low

1212386

GPTC4
G patch domain-containing protein 4

1

0

High-throughput

0.232

Low

1241516

EDC4
Enhancer of mRNA-decapping protein 4

1

0

High-throughput

0.232

Low

1247860

MAP12
Methionine aminopeptidase 1D, mitochondrial

1

0

High-throughput

0.232

Low

1248449

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

0

High-throughput

0.232

Low

1278824

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.232

Low

1292244

LONP2
Lon protease homolog 2, peroxisomal

1

0

High-throughput

0.232

Low

1358130

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.232

Low

1358392

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.232

Low

1371557

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

0

High-throughput

0.232

Low

1394274

GMCL1
Germ cell-less protein-like 1

1

0

High-throughput

0.232

Low

1432816

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.232

Low

1435188

RPAP3
RNA polymerase II-associated protein 3

1

0

High-throughput

0.232

Low

1436710

GORS2
Golgi reassembly-stacking protein 2

1

0

High-throughput

0.232

Low

1437268

FKRP
Ribitol 5-phosphate transferase FKRP

1

0

High-throughput

0.232

Low

1449185

CHST7
Carbohydrate sulfotransferase 7

1

0

High-throughput

0.232

Low

1458402

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

High-throughput

0.232

Low

1458406

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.232

Low

1458410

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.232

Low

1458412

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.232

Low

1458415

NOP16
Nucleolar protein 16

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025