HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UBE2U (Q5VVX9)
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)
Gene: UBE2U

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	30097011
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1058 Hs			1 321
+	Hs
		607190 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33
+	Hs
		607026 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00
+	Hs
		607050 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67
+	Hs
		607039 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00
+	Hs
		607136 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E2_HUMAN (3-153): 5.78e-68: 212: 23.18
+	Hs
		607129 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E3_HUMAN (3-153): 1.57e-67: 211: 24.50
+	Hs
		607023 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2A_HUMAN (1-151): 5.75e-68: 210: 33.11
+	Hs
		607028 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E1_HUMAN (3-153): 1.32e-66: 209: 25.17
+	Hs
		607054 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2B_HUMAN (1-151): 2.93e-67: 209: 31.79
+	Hs
		135923 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2C_HUMAN (9-145): 2.39e-20: 88.2: 35.77
+	Dm
		715098 Q8T0L3_DROME (36-1057): 0: 1108: 59.75		UBE2N_DROME (1-155): 1.39e-66: 207: 26.45
+	Sp
		293848 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (4-152): 2.89e-74: 226: 31.54
+	Sp
		251976 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC1_SCHPO (1-187): 3.79e-67: 211: 20.32
+	Sc
		549788 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (1-152): 1.07e-73: 225: 28.95
+	Hs
		48104 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00
+	Hs
		48107 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67
+	Hs
		48106 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00
+	Sp
		293847 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC2_SCHPO (9-140): 8.48e-20: 85.9: 34.09
+	Sp
		116508 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC11_SCHPO (9-144): 1.59e-18: 83.2: 34.31
+	Sc
		410211 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC2_YEAST (9-140): 7.7e-19: 84: 35.61