HitPredict

Interactor 1: CCL1 (P22362)
C-C motif chemokine 1 (Small-inducible cytokine A1) (T lymphocyte-secreted protein I-309)
Gene: CCL1

Interactor 2: CCR8 (P51685)
C-C chemokine receptor type 8 (C-C CKR-8) (CC-CKR-8) (CCR-8) (CC chemokine receptor CHEMR1) (CMKBRL2) (Chemokine receptor-like 1) (CKR-L1) (GPR-CY6) (GPRCY6) (TER1) (CD antigen CDw198)
Gene: CCR8

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	9211859, 10910894, 9469461, 11470772
Identification Methods	experimental interaction detection, biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0007186 - G protein-coupled receptor signaling pathway GO:0007204 - positive regulation of cytosolic calcium ion concentration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 96 Hs			1 355
+	Hs
		486237 CCL3_HUMAN (1-92): 6.05e-34: 113: 33.70		CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64
+	Hs
		561732 CL3L1_HUMAN (1-92): 1.65e-33: 112: 35.48		CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64
+	Hs
		526564 CCL4_HUMAN (1-91): 6.37e-32: 108: 30.44		CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64
+	Hs
		849619 CCL13_HUMAN (1-96): 7.33e-32: 108: 30.93		CCR3_HUMAN (1-346): 6.44e-92: 280: 37.64
+	Hs
		134354 CCL3_HUMAN (1-92): 6.05e-34: 113: 33.70		ACKR2_HUMAN (10-315): 1.56e-81: 255: 36.33
+	Hs
		486231 CCL3_HUMAN (1-92): 6.05e-34: 113: 33.70		CXCR5_HUMAN (3-346): 3.32e-81: 253: 27.71
+	Hs
		134356 CCL4_HUMAN (1-91): 6.37e-32: 108: 30.44		ACKR2_HUMAN (10-315): 1.56e-81: 255: 36.33
+	Hs
		134400 CCL13_HUMAN (1-96): 7.33e-32: 108: 30.93		ACKR2_HUMAN (10-315): 1.56e-81: 255: 36.33
+	Hs
		526561 CCL4_HUMAN (1-91): 6.37e-32: 108: 30.44		CXCR5_HUMAN (3-346): 3.32e-81: 253: 27.71
+	Hs
		486230 CCL3_HUMAN (1-92): 6.05e-34: 113: 33.70		CCR1_HUMAN (15-345): 6.58e-77: 242: 41.44
+	Hs
		486238 CCL3_HUMAN (1-92): 6.05e-34: 113: 33.70		CCR4_HUMAN (2-355): 9.67e-77: 242: 43.10
+	Mm
		500591 CCL3_MOUSE (1-92): 9.77e-32: 108: 35.48		CCR3_MOUSE (9-345): 4.69e-79: 247: 41.30
+	Hs
		561728 CL3L1_HUMAN (1-92): 1.65e-33: 112: 35.48		CCR1_HUMAN (15-345): 6.58e-77: 242: 41.44
+	Hs
		783833 CCL13_HUMAN (1-96): 7.33e-32: 108: 30.93		CCR2_HUMAN (6-328): 2.8e-77: 243: 39.51
+	Hs
		526560 CCL4_HUMAN (1-91): 6.37e-32: 108: 30.44		CCR1_HUMAN (15-345): 6.58e-77: 242: 41.44
+	Hs
		486239 CCL3_HUMAN (1-92): 6.05e-34: 113: 33.70		CCR5_HUMAN (1-352): 1.66e-72: 230: 40.11
+	Hs
		561733 CL3L1_HUMAN (1-92): 1.65e-33: 112: 35.48		CCR5_HUMAN (1-352): 1.66e-72: 230: 40.11
+	Hs
		526565 CCL4_HUMAN (1-91): 6.37e-32: 108: 30.44		CCR5_HUMAN (1-352): 1.66e-72: 230: 40.11
+	Hs
		849654 CCL13_HUMAN (1-96): 7.33e-32: 108: 30.93		CCR5_HUMAN (1-352): 1.66e-72: 230: 40.11
+	Mm
		500590 CCL3_MOUSE (1-92): 9.77e-32: 108: 35.48		CCR1_MOUSE (3-345): 6.18e-72: 229: 39.13