Protein: PTN2
Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP)

Gene: PTN2, PTPN2
Organism: Homo sapiens
Interactions: 208
UniProt ID: P17706

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity
GO:0005178 - integrin binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

607539

STAT3
Signal transducer and activator of transcription 3

7

18

Small-scale

0.959

High

362729

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.806

High

607524

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

18

High-throughput

0.776

High

607542

STAT1
Signal transducer and activator of transcription 1-alpha/beta

2

17

Small-scale

0.776

High

533826

GHR
Growth hormone receptor

1

20

Small-scale

0.770

High

607543

STAT6
Signal transducer and activator of transcription 6

1

17

Small-scale

0.747

High

557071

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.724

High

607534

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.724

High

295452

PSD10
26S proteasome non-ATPase regulatory subunit 10

4

10

High-throughput

0.691

High

607566

PRS4
26S proteasome regulatory subunit 4

4

5

High-throughput

0.691

High

607601

S39A4
Zinc transporter ZIP4

4

12

High-throughput

0.691

High

607567

PRS8
26S proteasome regulatory subunit 8

3

6

High-throughput

0.667

High

607536

TNFL8
Tumor necrosis factor ligand superfamily member 8

3

1

High-throughput

0.662

High

607526

CO5A1

3

2

High-throughput

0.657

High

253581

IMA7
Importin subunit alpha-7

3

2

High-throughput

0.656

High

607559

IMA5
Importin subunit alpha-5

3

2

High-throughput

0.656

High

607560

PSMD4
26S proteasome non-ATPase regulatory subunit 4

3

3

High-throughput

0.656

High

607583

PSMD2
26S proteasome non-ATPase regulatory subunit 2

3

8

High-throughput

0.650

High

455900

ASGR1
Asialoglycoprotein receptor 1

2

11

High-throughput

0.628

High

607593

C3AR
C3a anaphylatoxin chemotactic receptor

2

12

High-throughput

0.628

High

607603

S39A5
Zinc transporter ZIP5

2

12

High-throughput

0.628

High

607666

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

20

High-throughput

0.628

High

439634

INSR
Insulin receptor

1

20

Small-scale

0.618

High

607522

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

17

High-throughput

0.618

High

607597

PTN20
Tyrosine-protein phosphatase non-receptor type 20

1

17

High-throughput

0.618

High

607604

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

607623

CSKI1
Caskin-1

1

14

High-throughput

0.618

High

137949

PSDE
26S proteasome non-ATPase regulatory subunit 14

2

4

High-throughput

0.611

High

607537

PRS7
26S proteasome regulatory subunit 7

2

5

High-throughput

0.611

High

607547

PRS6B
26S proteasome regulatory subunit 6B

2

5

High-throughput

0.611

High

607568

PRS10
26S proteasome regulatory subunit 10B

2

6

High-throughput

0.611

High

607577

APLP2
Amyloid beta precursor like protein 2

2

4

High-throughput

0.611

High

607590

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

7

High-throughput

0.611

High

607638

PSMD1
26S proteasome non-ATPase regulatory subunit 1

2

8

High-throughput

0.611

High

607671

NUP50
Nuclear pore complex protein Nup50

2

1

High-throughput

0.611

High

219271

B4GA1
Beta-1,4-glucuronyltransferase 1

3

1

High-throughput

0.604

High

328806

CSPG5
Chondroitin sulfate proteoglycan 5

2

0

High-throughput

0.602

High

607580

TRAF2
TNF receptor-associated factor 2

2

8

Small-scale

0.601

High

607679

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

2

1

High-throughput

0.601

High

179023

IMA6
Importin subunit alpha-6

2

2

High-throughput

0.584

High

607548

PSMD8
26S proteasome non-ATPase regulatory subunit 8

2

1

High-throughput

0.584

High

607563

SC61B
Protein transport protein Sec61 subunit beta

2

3

High-throughput

0.584

High

607624

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

2

5

High-throughput

0.584

High

607675

PSD13
26S proteasome non-ATPase regulatory subunit 13

2

4

High-throughput

0.584

High

607588

IMB1
Importin subunit beta-1

1

8

Small-scale

0.578

High

607551

TMEDA
Transmembrane emp24 domain-containing protein 10

1

3

Small-scale

0.573

High

607643

TMED9
Transmembrane emp24 domain-containing protein 9

1

3

Small-scale

0.573

High

607562

STX17
Syntaxin-17

1

0

Small-scale

0.549

High

607606

F220A
Protein FAM220A

1

0

Small-scale

0.537

High

123580

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.536

High

141815

ACKR2
Atypical chemokine receptor 2

1

15

High-throughput

0.536

High

229646

CALU
Calumenin

1

6

High-throughput

0.536

High

421459

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.536

High

596453

CTLA4
Cytotoxic T-lymphocyte protein 4

1

3

High-throughput

0.536

High

607570

IF5A1
Eukaryotic translation initiation factor 5A-1

1

2

High-throughput

0.536

High

607571

TPM4
Tropomyosin alpha-4 chain

1

2

High-throughput

0.536

High

607581

TSN31
Tetraspanin-31

1

1

High-throughput

0.536

High

607595

DREB
Drebrin

1

1

High-throughput

0.536

High

607620

SETD7
Histone-lysine N-methyltransferase SETD7

1

2

High-throughput

0.536

High

607622

SPRY4
SPRY domain-containing protein 4

1

3

High-throughput

0.536

High

607646

STRA6
Receptor for retinol uptake STRA6

1

1

High-throughput

0.536

High

607674

TNF18
Tumor necrosis factor ligand superfamily member 18

1

1

High-throughput

0.536

High

464673

CXB1
Gap junction beta-1 protein

1

6

Small-scale

0.519

High

607535

1433S
14-3-3 protein sigma

1

16

High-throughput

0.515

High

551688

HARS1
Histidine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.513

High

607538

COIL
Coilin

1

0

High-throughput

0.513

High

607573

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

481080

HMGB1
High mobility group protein B1

1

1

Small-scale

0.508

High

384364

CRYAA
Alpha-crystallin A chain

1

4

High-throughput

0.501

High

507504

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

607594

OCLN
Occludin

1

1

Small-scale

0.501

High

607558

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.493

High

136474

GOLI4
Golgi integral membrane protein 4

1

10

High-throughput

0.489

High

607540

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.489

High

607600

GOLM2
Protein GOLM2

1

1

High-throughput

0.489

High

607663

TMOD3
Tropomodulin-3

1

1

High-throughput

0.489

High

607672

COR1C
Coronin-1C

1

7

High-throughput

0.489

High

127871

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

12

High-throughput

0.479

High

128139

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

11

High-throughput

0.479

High

173851

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

8

High-throughput

0.479

High

210852

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

215250

TXNL1
Thioredoxin-like protein 1

1

16

High-throughput

0.479

High

215868

AN32C
Putative uncharacterized protein ANP32CP

1

3

High-throughput

0.479

High

229950

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

3

High-throughput

0.479

High

240689

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

259404

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

291204

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.479

High

385437

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

High-throughput

0.479

High

417253

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

417938

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.479

High

466099

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

486936

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

536452

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

580864

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

607523

PRS6A
26S proteasome regulatory subunit 6A

1

15

High-throughput

0.479

High

607525

PSB1
Proteasome subunit beta type-1

1

9

High-throughput

0.479

High

607527

PSA1
Proteasome subunit alpha type-1

1

5

High-throughput

0.479

High

607528

PSA2
Proteasome subunit alpha type-2

1

6

High-throughput

0.479

High

607529

PSA3
Proteasome subunit alpha type-3

1

5

High-throughput

0.479

High

607530

PSA4
Proteasome subunit alpha type-4

1

5

High-throughput

0.479

High

607531

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.479

High

607532

PSB4
Proteasome subunit beta type-4

1

9

High-throughput

0.479

High

607533

PSB5
Proteasome subunit beta type-5

1

5

High-throughput

0.479

High

607541

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

607544

RBM34
RNA-binding protein 34

1

1

High-throughput

0.479

High

607545

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

607546

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.479

High

607549

PSB3
Proteasome subunit beta type-3

1

5

High-throughput

0.479

High

607550

PSB2
Proteasome subunit beta type-2

1

7

High-throughput

0.479

High

607552

NU153
Nuclear pore complex protein Nup153

1

9

High-throughput

0.479

High

607553

EMD
Emerin

1

1

High-throughput

0.479

High

607554

RAB9A
Ras-related protein Rab-9A

1

9

High-throughput

0.479

High

607555

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

607556

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

4

High-throughput

0.479

High

607561

ITA1
Integrin alpha-1

1

11

Small-scale

0.479

High

607564

PSA6
Proteasome subunit alpha type-6

1

6

High-throughput

0.479

High

607565

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

607569

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.479

High

607572

RPP30
Ribonuclease P protein subunit p30

1

1

High-throughput

0.479

High

607574

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

607575

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

607576

UBE3A
Ubiquitin-protein ligase E3A

1

8

Small-scale

0.479

High

607578

CKAP4
Cytoskeleton-associated protein 4

1

4

High-throughput

0.479

High

607584

TIF1B
Transcription intermediary factor 1-beta

1

4

High-throughput

0.479

High

607596

CAH9
Carbonic anhydrase 9

1

7

High-throughput

0.479

High

607609

DJC10
DnaJ homolog subfamily C member 10

1

20

High-throughput

0.479

High

607610

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

1

High-throughput

0.479

High

607611

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

2

High-throughput

0.479

High

607612

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.479

High

607615

DHB11
Estradiol 17-beta-dehydrogenase 11

1

4

High-throughput

0.479

High

607616

TXND5
Thioredoxin domain-containing protein 5

1

16

High-throughput

0.479

High

607618

G45IP
Large ribosomal subunit protein mL64

1

1

High-throughput

0.479

High

607626

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

3

High-throughput

0.479

High

607627

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.479

High

607628

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.479

High

607629

TECT2
Tectonic-2

1

3

High-throughput

0.479

High

607630

ZCCHL
Zinc finger CCCH-type antiviral protein 1-like

1

1

High-throughput

0.479

High

607631

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

1

High-throughput

0.479

High

607632

DNJC1
DnaJ homolog subfamily C member 1

1

18

High-throughput

0.479

High

607633

NSUN5
28S rRNA

1

4

High-throughput

0.479

High

607634

PANX1
Pannexin-1

1

1

High-throughput

0.479

High

607635

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

3

High-throughput

0.479

High

607636

PSB7
Proteasome subunit beta type-7

1

3

High-throughput

0.479

High

607637

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

607640

PAAF1
Proteasomal ATPase-associated factor 1

1

5

High-throughput

0.479

High

607641

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

3

High-throughput

0.479

High

607642

DERL1
Derlin-1

1

3

High-throughput

0.479

High

607647

LNP
Endoplasmic reticulum junction formation protein lunapark

1

2

High-throughput

0.479

High

607650

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.479

High

607652

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

607653

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

1

High-throughput

0.479

High

607657

ANLN
Anillin

1

2

High-throughput

0.479

High

607658

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.479

High

607661

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.479

High

607664

ELOV5
Very long chain fatty acid elongase 5

1

3

High-throughput

0.479

High

607665

TM216
Transmembrane protein 216

1

2

High-throughput

0.479

High

607668

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

607669

SEC63
Translocation protein SEC63 homolog

1

7

High-throughput

0.479

High

607670

XPO7
Exportin-7

1

13

High-throughput

0.479

High

607676

DIM1
Dimethyladenosine transferase

1

2

High-throughput

0.479

High

607681

DUS10
Dual specificity protein phosphatase 10

1

6

High-throughput

0.479

High

347517

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

426196

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

0

High-throughput

0.458

High

607579

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

607586

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

607587

BYST
Bystin

1

0

High-throughput

0.458

High

607592

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

High-throughput

0.458

High

607645

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

607656

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.458

High

607660

PNO1
RNA-binding protein PNO1

1

0

High-throughput

0.458

High

607662

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.458

High

607667

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.458

High

607678

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

0

High-throughput

0.458

High

133638

WASL
Actin nucleation-promoting factor WASL

1

9

Small-scale

0.445

High

189409

STX7
Syntaxin-7

1

6

High-throughput

0.445

High

303216

S22A5
Organic cation/carnitine transporter 2

1

2

High-throughput

0.445

High

607557

CCR6
C-C chemokine receptor type 6

1

15

High-throughput

0.445

High

607582

TRDN
Triadin

1

4

High-throughput

0.445

High

607585

STX3
Syntaxin-3

1

7

High-throughput

0.445

High

607598

S39AC
Zinc transporter ZIP12

1

12

High-throughput

0.445

High

607605

MOT9
Monocarboxylate transporter 9

1

6

High-throughput

0.445

High

607608

STX12
Syntaxin-12

1

6

High-throughput

0.445

High

607617

MSPD2
Motile sperm domain-containing protein 2

1

4

High-throughput

0.445

High

607639

CML1
Chemerin-like receptor 1

1

15

High-throughput

0.445

High

607655

SDF2L
Stromal cell-derived factor 2-like protein 1

1

3

High-throughput

0.445

High

607673

CLC4A
C-type lectin domain family 4 member A

1

14

High-throughput

0.445

High

607680

FLVC1
Choline/ethanolamine transporter FLVCR1

1

2

High-throughput

0.445

High

607589

T132D
Transmembrane protein 132D

1

2

Small-scale

0.439

High

607591

UBE3C
Ubiquitin-protein ligase E3C

1

8

High-throughput

0.437

High

607607

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

607614

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

3

High-throughput

0.437

High

607619

BRX1
Ribosome biogenesis protein BRX1 homolog

1

3

High-throughput

0.437

High

607621

TFB1M
Dimethyladenosine transferase 1, mitochondrial

1

2

High-throughput

0.437

High

607648

DJC25
DnaJ homolog subfamily C member 25

1

12

High-throughput

0.437

High

607649

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.437

High

607651

CH033
UPF0488 protein C8orf33

1

1

High-throughput

0.437

High

607659

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.437

High

607677

DJC16
DnaJ homolog subfamily C member 16

1

20

High-throughput

0.437

High

62094

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

16

High-throughput

0.407

High

607599

TMM31
Transmembrane protein 31

1

1

High-throughput

0.407

High

61898

GTPBA
GTP-binding protein 10

1

0

High-throughput

0.249

Low

607625

RL3L
Ribosomal protein uL3-like

1

0

High-throughput

0.249

Low

607644

TR61B
tRNA

1

0

High-throughput

0.249

Low

607654

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.249

Low

547963

PSPC
Surfactant protein C

1

0

High-throughput

0.232

Low

607602

SPNS3
Protein spinster homolog 3

1

0

High-throughput

0.232

Low

607613

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025