HitPredict

Interactor 1: UBA1 (P22515)
Ubiquitin-activating enzyme E1 1 (EC 6.2.1.45)
Gene: UBA1

Interactor 2: UBC9 (P50623)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (Ubiquitin carrier protein 9) (Ubiquitin-conjugating enzyme E2-18 kDa) (Ubiquitin-protein ligase)
Gene: UBC9

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21209884
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1024 Sc			1 157
+	Sc
		549788 UBA1_YEAST (1-1024): 0: 1089: 100.00		UBC4_YEAST (1-156): 3.15e-72: 215: 33.33
+	Sp
		293848 UBA1_SCHPO (1-1024): 0: 1038: 58.29		UBC4_SCHPO (4-156): 3.4e-72: 215: 33.33
+	Hs
		48104 UBA6_HUMAN (2-1024): 0: 966: 40.81		UB2D1_HUMAN (4-156): 1.54e-73: 218: 33.99
+	Hs
		48107 UBA6_HUMAN (2-1024): 0: 966: 40.81		UB2D2_HUMAN (4-156): 2.79e-73: 217: 32.68
+	Hs
		48106 UBA6_HUMAN (2-1024): 0: 966: 40.81		UB2D3_HUMAN (4-156): 3.32e-72: 215: 32.68
+	Sp
		116506 UBA1_SCHPO (1-1024): 0: 1038: 58.29		UBC7_SCHPO (3-154): 1.67e-25: 97.1: 33.74
+	Hs
		782203 UBA7_HUMAN (5-1024): 0: 909: 36.99		UB2E1_HUMAN (3-156): 3.29e-66: 201: 31.82
+	At
		1115004 SAE2_ARATH (31-482): 1.99e-78: 273: 16.12		SCE1_ARATH (2-155): 7.8e-73: 216: 59.74
+	Hs
		930429 SAE2_HUMAN (24-413): 8.43e-82: 280: 15.72		UBC9_HUMAN (1-156): 5.53e-69: 207: 56.41
+	Hs
		1282360 SAE2_HUMAN (24-413): 8.43e-82: 280: 15.72		UB2E3_HUMAN (3-156): 1.16e-67: 205: 31.17
+	Dm
		1181395 Q7KUA4_DROME (25-417): 2.89e-76: 267: 13.57		Q7KNM2_DROME (1-156): 5.99e-73: 217: 53.85
+	Sc
		841408 UBA2_YEAST (25-426): 1.8e-67: 240: 16.18		UBC9_YEAST (1-157): 4.84e-76: 225: 100.00
+	Hs
		930427 SAE1_HUMAN (409-706): 1.78e-61: 215: 20.46		UBC9_HUMAN (1-156): 5.53e-69: 207: 56.41
+	Sc
		841442 RHC31_YEAST (407-577): 1.41e-41: 158: 22.81		UBC9_YEAST (1-157): 4.84e-76: 225: 100.00
+	Hs
		919796 UBA3_HUMAN (790-994): 5.83e-41: 159: 14.55		UB2D2_HUMAN (4-156): 2.79e-73: 217: 32.68
+	Dm
		1181392 Q7KSM5_DROME (408-574): 6.88e-38: 147: 22.16		Q7KNM2_DROME (1-156): 5.99e-73: 217: 53.85
+	Hs
		607026 UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75		UB2D1_HUMAN (4-156): 1.54e-73: 218: 33.99
+	Hs
		607039 UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75		UB2D3_HUMAN (4-156): 3.32e-72: 215: 32.68
+	Hs
		607023 UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75		UBE2A_HUMAN (1-154): 1.04e-66: 201: 38.96
+	Hs
		607028 UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75		UB2E1_HUMAN (3-156): 3.29e-66: 201: 31.82