HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: SH2B1 (Q9NRF2)
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)
Gene: SH2B1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11827956
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 756
+	Mm
		1143162 FGFR3_MOUSE (1-806): 0: 793: 92.32		SH2B2_MOUSE (25-755): 2.98e-133: 409: 34.47
+	Hs
		580927 FGFR3_HUMAN (10-806): 0: 819: 100.00		PLCG1_HUMAN (451-753): 3.41e-69: 249: 17.19
+	Hs
		872612 EPHB1_HUMAN (1-787): 0: 642: 18.08		GRB10_HUMAN (82-618): 1.38e-92: 302: 12.05
+	Hs
		872614 EPHB1_HUMAN (1-787): 0: 642: 18.08		GRB7_HUMAN (99-613): 1.08e-80: 269: 12.89
+	Hs
		609244 FGFR3_HUMAN (10-806): 0: 819: 100.00		GRB2_HUMAN (517-646): 2.75e-16: 80.5: 18.46
+	Hs
		412036 EPHA3_HUMAN (1-786): 0: 641: 20.68		FYN_HUMAN (401-742): 2.99e-74: 252: 13.87
+	Hs
		522802 EPHA3_HUMAN (1-786): 0: 641: 20.68		SRC_HUMAN (376-742): 1.26e-71: 245: 13.88
+	Hs
		433265 EPHB2_HUMAN (1-788): 0: 624: 19.15		YES_HUMAN (356-742): 4.3e-76: 257: 14.25
+	Mm
		763386 EPHA4_MOUSE (1-781): 0: 626: 20.78		FYN_MOUSE (401-742): 4.56e-74: 251: 13.87
+	Hs
		412105 EPHA4_HUMAN (1-781): 0: 622: 20.78		FYN_HUMAN (401-742): 2.99e-74: 252: 13.87
+	Mm
		403425 EPHB2_MOUSE (1-788): 0: 624: 19.03		SRC_MOUSE (376-742): 2.81e-73: 249: 13.68
+	Hs
		580937 EPHB2_HUMAN (1-788): 0: 624: 19.15		PLCG1_HUMAN (451-753): 3.41e-69: 249: 17.19
+	Hs
		522803 EPHB2_HUMAN (1-788): 0: 624: 19.15		SRC_HUMAN (376-742): 1.26e-71: 245: 13.88
+	Hs
		522871 EPHA4_HUMAN (1-781): 0: 622: 20.78		SRC_HUMAN (376-742): 1.26e-71: 245: 13.88
+	Hs
		562635 EPHA4_HUMAN (1-781): 0: 622: 20.78		PLCG2_HUMAN (507-753): 4.8e-47: 183: 17.11
+	Mm
		872621 EPHB2_MOUSE (1-788): 0: 624: 19.03		GRB2_MOUSE (506-648): 1.34e-40: 150: 17.48
+	Hs
		872610 EPHB1_HUMAN (1-787): 0: 642: 18.08		GRB2_HUMAN (517-646): 2.75e-16: 80.5: 18.46
+	Hs
		665389 EPHA3_HUMAN (1-786): 0: 641: 20.68		GRB2_HUMAN (517-646): 2.75e-16: 80.5: 18.46
+	Hs
		924590 EPHA7_HUMAN (1-782): 0: 626: 21.22		GRB2_HUMAN (517-646): 2.75e-16: 80.5: 18.46
+	Hs
		665574 EPHB2_HUMAN (1-788): 0: 624: 19.15		GRB2_HUMAN (517-646): 2.75e-16: 80.5: 18.46