Protein: SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)

Gene: SIR5, SIRT5
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q9NXA8

Gene Ontology (top 5):
GO:0002931 - response to ischemia
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005758 - mitochondrial intermembrane space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

478735

HXB5
Homeobox protein Hox-B5

3

10

High-throughput

0.667

High

1451920

CWC15
Spliceosome-associated protein CWC15 homolog

3

1

High-throughput

0.667

High

322327

GLSK
Glutaminase kidney isoform, mitochondrial

3

2

Small-scale

0.640

High

946538

YBEY
Endoribonuclease YbeY

2

1

High-throughput

0.628

High

1309841

WDFY1
WD repeat and FYVE domain-containing protein 1

2

5

High-throughput

0.628

High

1449508

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

13

Small-scale

0.618

High

192026

GLYG2
Glycogenin-2

2

0

High-throughput

0.602

High

1211857

THEM4
Acyl-coenzyme A thioesterase THEM4

2

0

High-throughput

0.602

High

1358063

CPLX3
Complexin-3

2

0

High-throughput

0.602

High

623571

RO52
E3 ubiquitin-protein ligase TRIM21

1

3

Small-scale

0.578

High

1451919

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

13

High-throughput

0.575

High

1371735

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

13

Small-scale

0.561

High

425965

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

5

High-throughput

0.536

High

543546

VDR
Vitamin D3 receptor

1

18

High-throughput

0.536

High

547491

DMD
Dystrophin

1

8

High-throughput

0.536

High

605223

TAL1
T-cell acute lymphocytic leukemia protein 1

1

5

High-throughput

0.536

High

634889

HXA5
Homeobox protein Hox-A5

1

9

High-throughput

0.536

High

856951

BAG6
Large proline-rich protein BAG6

1

8

High-throughput

0.536

High

913996

RBM5
RNA-binding protein 5

1

9

High-throughput

0.536

High

1024883

VIGLN
Vigilin

1

6

High-throughput

0.536

High

1025232

HXC5
Homeobox protein Hox-C5

1

10

High-throughput

0.536

High

1120366

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

5

High-throughput

0.536

High

1228864

ZN776
Zinc finger protein 776

1

1

High-throughput

0.536

High

1348730

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

2

High-throughput

0.536

High

1389024

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

1

High-throughput

0.536

High

1398952

ZMAT2
Zinc finger matrin-type protein 2

1

2

High-throughput

0.536

High

1430162

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

2

High-throughput

0.536

High

829571

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.515

High

1312901

ETKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

1

0

High-throughput

0.513

High

1405056

SORT
Sortilin

1

0

High-throughput

0.513

High

414726

P53
Cellular tumor antigen p53

1

6

Small-scale

0.501

High

423316

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

302713

SYUG
Gamma-synuclein

1

0

High-throughput

0.493

High

1314578

CKP2L
Cytoskeleton-associated protein 2-like

1

0

High-throughput

0.493

High

1024003

HXA4
Homeobox protein Hox-A4

1

9

High-throughput

0.489

High

1279502

SNX20
Sorting nexin-20

1

6

High-throughput

0.489

High

1389514

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

4

High-throughput

0.489

High

1451921

PCD10
Protocadherin-10

1

1

High-throughput

0.489

High

157919

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

260536

BRD4
Bromodomain-containing protein 4

1

14

Small-scale

0.479

High

279951

CISY
Citrate synthase, mitochondrial

1

6

Small-scale

0.479

High

373309

MYC
Myc proto-oncogene protein

1

7

Small-scale

0.479

High

659306

SP100
Nuclear autoantigen Sp-100

1

7

High-throughput

0.479

High

761049

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

Small-scale

0.479

High

831530

CCNF
Cyclin-F

1

4

Small-scale

0.479

High

867461

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

877395

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

Small-scale

0.479

High

932952

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

9

Small-scale

0.479

High

1045840

TF65
Transcription factor p65

1

7

Small-scale

0.479

High

1255815

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1316247

DOCK3
Dedicator of cytokinesis protein 3

1

4

High-throughput

0.479

High

1391805

AURKB
Aurora kinase B

1

6

High-throughput

0.479

High

1451287

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

340417

YETS4
YEATS domain-containing protein 4

1

2

High-throughput

0.445

High

1420673

UNK
RING finger protein unkempt homolog

1

2

High-throughput

0.445

High

1451922

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

380720

HBAZ
Hemoglobin subunit zeta

2

0

High-throughput

0.328

High

1205046

RABL3
Rab-like protein 3

2

0

High-throughput

0.328

High

1251695

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1252733

GBP6
Guanylate-binding protein 6

1

0

High-throughput

0.279

Low

1293023

CDR2L
Cerebellar degeneration-related protein 2-like

1

0

High-throughput

0.279

Low

1432873

SEM4A
Semaphorin-4A

1

0

High-throughput

0.279

Low

1451923

GHRL
Appetite-regulating hormone

1

0

High-throughput

0.279

Low

377750

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1451924

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1312865

GPAM1
GPALPP motifs-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025