HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

Property	Details
Experiments	12147253, 22509030, 12496371, 32737118, 23874206
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cbl_N~fn3, Cbl_N2~fn3, Cbl_N3~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 976
+	Hs
		610314 CBL_HUMAN (1-906): 0: 917: 100.00		EPHB1_HUMAN (27-973): 0: 1106: 47.26
+	Hs
		610245 CBL_HUMAN (1-906): 0: 917: 100.00		EPHA8_HUMAN (28-975): 0: 1049: 46.72
+	Hs
		665361 CBLC_HUMAN (42-504): 0: 620: 42.07		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		610252 CBL_HUMAN (1-906): 0: 917: 100.00		UFO_HUMAN (294-911): 1.98e-146: 459: 24.49
+	Hs
		435537 CBL_HUMAN (1-906): 0: 917: 100.00		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		665647 ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25		EPHB2_HUMAN (28-973): 0: 1089: 48.29
+	Hs
		442780 CBL_HUMAN (1-906): 0: 917: 100.00		HCK_HUMAN (591-880): 1.46e-65: 231: 42.12
+	Hs
		433577 CBL_HUMAN (1-906): 0: 917: 100.00		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Mm
		435877 CBL_MOUSE (1-906): 0: 888: 91.59		HCK_MOUSE (591-880): 3.56e-64: 228: 40.75
+	Mm
		610545 CBL_MOUSE (1-906): 0: 888: 91.59		LYN_MOUSE (607-879): 1.97e-64: 228: 42.91
+	Hs
		600594 OTOG_HUMAN (405-893): 1.88e-23: 109: 12.85		EPHA1_HUMAN (17-967): 0: 959: 49.38
+	Rn
		88775 D3ZV15_RAT (1-883): 0: 833: 89.00		LYN_RAT (607-879): 1.29e-64: 228: 42.91
+	Mm
		82734 B9EKI5_MOUSE (23-901): 0: 799: 47.22		LYN_MOUSE (607-879): 1.97e-64: 228: 42.91
+	Ce
		220228 Q6ABG8_CAEEL (43-510): 0: 662: 48.24		SRC2_CAEEL (607-880): 4.16e-65: 229: 41.97
+	Ce
		220219 Q19019_CAEEL (49-546): 0: 639: 44.12		SRC2_CAEEL (607-880): 4.16e-65: 229: 41.97
+	Hs
		434075 CBLC_HUMAN (42-504): 0: 620: 42.07		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		297808 K0754_HUMAN (395-794): 1.98e-40: 164: 11.17		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		433853 MICA3_HUMAN (406-905): 3.1e-14: 79.6: 11.67		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		433560 MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		433948 ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91