HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: EPHA8 (P29322)
Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK)
Gene: EPHA8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20100865
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cbl_N~fn3, Cbl_N2~fn3, Cbl_N3~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 1005
+	Hs
		610314 CBL_HUMAN (1-906): 0: 917: 100.00		EPHB1_HUMAN (31-999): 0: 1215: 51.53
+	Hs
		610244 CBL_HUMAN (1-906): 0: 917: 100.00		EPHA2_HUMAN (30-1001): 0: 1097: 46.78
+	Hs
		665361 CBLC_HUMAN (42-504): 0: 620: 42.07		EPHA2_HUMAN (30-1001): 0: 1097: 46.78
+	Hs
		610252 CBL_HUMAN (1-906): 0: 917: 100.00		UFO_HUMAN (264-981): 3.57e-161: 499: 22.34
+	Hs
		610359 CBL_HUMAN (1-906): 0: 917: 100.00		TIE2_HUMAN (328-897): 9.41e-141: 452: 26.28
+	Hs
		610366 CBL_HUMAN (1-906): 0: 917: 100.00		FAK1_HUMAN (612-901): 4.66e-59: 222: 41.03
+	Hs
		433577 CBL_HUMAN (1-906): 0: 917: 100.00		LYN_HUMAN (629-900): 2.17e-59: 214: 41.39
+	Hs
		412013 CBL_HUMAN (1-906): 0: 917: 100.00		FYN_HUMAN (629-900): 6.44e-59: 213: 41.76
+	Hs
		600594 OTOG_HUMAN (405-893): 1.88e-23: 109: 12.85		EPHA1_HUMAN (7-993): 0: 1017: 40.18
+	Mm
		411917 CBL_MOUSE (1-906): 0: 888: 91.59		LCK_MOUSE (611-900): 2.61e-59: 214: 39.52
+	Mm
		435877 CBL_MOUSE (1-906): 0: 888: 91.59		HCK_MOUSE (595-901): 2.18e-59: 214: 37.99
+	Hs
		983599 CBLB_HUMAN (23-901): 0: 793: 46.65		FAK1_HUMAN (612-901): 4.66e-59: 222: 41.03
+	Hs
		412170 CBLB_HUMAN (23-901): 0: 793: 46.65		FYN_HUMAN (629-900): 6.44e-59: 213: 41.76
+	Mm
		411924 CBLB_MOUSE (23-901): 0: 791: 45.98		LCK_MOUSE (611-900): 2.61e-59: 214: 39.52
+	Ce
		220228 Q6ABG8_CAEEL (43-510): 0: 662: 48.24		SRC2_CAEEL (629-909): 8.49e-62: 221: 41.34
+	Ce
		220219 Q19019_CAEEL (49-546): 0: 639: 44.12		SRC2_CAEEL (629-909): 8.49e-62: 221: 41.34
+	Hs
		434075 CBLC_HUMAN (42-504): 0: 620: 42.07		LYN_HUMAN (629-900): 2.17e-59: 214: 41.39
+	Hs
		412405 CBLC_HUMAN (42-504): 0: 620: 42.07		FYN_HUMAN (629-900): 6.44e-59: 213: 41.76
+	Hs
		297808 K0754_HUMAN (395-794): 1.98e-40: 164: 11.17		LYN_HUMAN (629-900): 2.17e-59: 214: 41.39
+	Hs
		412362 MAGE1_HUMAN (527-872): 1.47e-14: 80.4: 12.36		FYN_HUMAN (629-900): 6.44e-59: 213: 41.76