HitPredict

Interactor 1: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Interactor 2: RD23A (P54725)
UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)
Gene: RAD23A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19013454
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 439 Hs			1 363
+	Hs
		931486 PRS4_HUMAN (32-433): 9.24e-134: 393: 43.60		RD23A_HUMAN (1-363): 3.22e-117: 345: 100.00
+	Rn
		1195203 PRS6A_RAT (1-439): 9.81e-139: 406: 99.32		RD23B_RAT (3-363): 5.22e-107: 321: 52.05
+	Hs
		610278 PRS6A_HUMAN (1-439): 2.6e-139: 408: 100.00		RD23B_HUMAN (3-363): 2.98e-104: 314: 54.03
+	Hs
		931487 PRS8_HUMAN (65-437): 1.52e-124: 369: 44.39		RD23A_HUMAN (1-363): 3.22e-117: 345: 100.00
+	Rn
		968861 PRS4_RAT (32-433): 9.24e-134: 393: 43.60		RD23B_RAT (3-363): 5.22e-107: 321: 52.05
+	Hs
		931640 PRS4_HUMAN (32-433): 9.24e-134: 393: 43.60		RD23B_HUMAN (3-363): 2.98e-104: 314: 54.03
+	Hs
		931641 PRS8_HUMAN (65-437): 1.52e-124: 369: 44.39		RD23B_HUMAN (3-363): 2.98e-104: 314: 54.03
+	Dm
		1464682 Q9V405_DROME (3-438): 3.06e-128: 378: 37.39		Q9V3W9_DROME (3-362): 2.29e-85: 266: 38.19
+	At
		1456607 PRS4A_ARATH (34-433): 6.62e-155: 447: 44.06		DSK2A_ARATH (1-318): 1.91e-43: 159: 15.17
+	Dm
		875008 PRS4_DROME (5-433): 1.77e-133: 392: 42.49		Q9VCD5_DROME (3-362): 6.41e-57: 188: 27.90
+	Hs
		610508 PRS6A_HUMAN (1-439): 2.6e-139: 408: 100.00		UBQL1_HUMAN (2-312): 1.52e-47: 171: 14.47
+	Hs
		610498 PRS6A_HUMAN (1-439): 2.6e-139: 408: 100.00		UBQL2_HUMAN (2-312): 4.48e-45: 165: 16.08
+	Hs
		610485 PRS6A_HUMAN (1-439): 2.6e-139: 408: 100.00		UBQL4_HUMAN (3-312): 1.49e-44: 163: 15.87
+	Hs
		968832 PRS4_HUMAN (32-433): 9.24e-134: 393: 43.60		UBQL1_HUMAN (2-312): 1.52e-47: 171: 14.47
+	Dm
		1267714 Q7KMQ0_DROME (21-433): 1.07e-124: 370: 37.11		Q9VCD5_DROME (3-362): 6.41e-57: 188: 27.90
+	Hs
		968827 PRS4_HUMAN (32-433): 9.24e-134: 393: 43.60		UBQL2_HUMAN (2-312): 4.48e-45: 165: 16.08
+	Hs
		968815 PRS4_HUMAN (32-433): 9.24e-134: 393: 43.60		UBQL4_HUMAN (3-312): 1.49e-44: 163: 15.87
+	Hs
		968680 PRS4_HUMAN (32-433): 9.24e-134: 393: 43.60		RL40_HUMAN (3-129): 3.34e-38: 134: 22.84
+	Hs
		610293 PRS6A_HUMAN (1-439): 2.6e-139: 408: 100.00		RS27A_HUMAN (3-93): 2.91e-16: 77.1: 27.47
+	Dm
		583696 Q9V3V6_DROME (26-439): 3.71e-127: 376: 85.75		RS27A_DROME (3-93): 5.67e-16: 76.4: 27.47