HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	31120930, 18508924, 18632619, 20675402
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cbl_N~UQ_con, UBA~UQ_con, UQ_con~zf-C3HC4
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 147
+	Hs
		610333 CBL_HUMAN (1-906): 0: 917: 100.00		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		610323 CBL_HUMAN (1-906): 0: 917: 100.00		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44
+	Hs
		610481 CBL_HUMAN (1-906): 0: 917: 100.00		UB2E2_HUMAN (4-146): 3.11e-74: 221: 62.94
+	Hs
		610469 CBL_HUMAN (1-906): 0: 917: 100.00		UB2E3_HUMAN (4-146): 1.2e-73: 220: 62.94
+	Hs
		610307 CBL_HUMAN (1-906): 0: 917: 100.00		UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94
+	Hs
		610325 CBL_HUMAN (1-906): 0: 917: 100.00		UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83
+	Hs
		919717 CBLB_HUMAN (23-901): 0: 793: 46.65		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Mm
		895981 CBLB_MOUSE (23-901): 0: 791: 45.98		UB2D1_MOUSE (1-147): 3.24e-82: 239: 100.00
+	Hs
		849487 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00
+	Hs
		919905 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		895953 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44