HitPredict

Interactor 1: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	12692129, 11278995
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 1083
+	Hs
		851327 PRS6B_HUMAN (1-399): 6.76e-119: 353: 41.86		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		778688 PRS7_HUMAN (84-392): 1.22e-115: 345: 56.31		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		975407 PRS10_HUMAN (11-123): 7.15e-10: 62.4: 9.74		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		968888 PRS8_HUMAN (1-406): 5.57e-135: 394: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		969062 PRS8_HUMAN (1-406): 5.57e-135: 394: 100.00		SMUF1_HUMAN (562-1080): 3.12e-177: 539: 22.78
+	Hs
		968688 PRS4_HUMAN (4-396): 1.69e-126: 374: 46.31		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		851295 PRS6B_HUMAN (1-399): 6.76e-119: 353: 41.86		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		778660 PRS7_HUMAN (84-392): 1.22e-115: 345: 56.31		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		851426 PRS6B_HUMAN (1-399): 6.76e-119: 353: 41.86		SMUF1_HUMAN (562-1080): 3.12e-177: 539: 22.78
+	Hs
		975383 PRS10_HUMAN (11-123): 7.15e-10: 62.4: 9.74		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		968973 PRS8_HUMAN (1-406): 5.57e-135: 394: 100.00		HUWE1_HUMAN (683-1083): 1.54e-47: 188: 32.60
+	Hs
		968748 PRS4_HUMAN (4-396): 1.69e-126: 374: 46.31		HUWE1_HUMAN (683-1083): 1.54e-47: 188: 32.60
+	Hs
		851362 PRS6B_HUMAN (1-399): 6.76e-119: 353: 41.86		HUWE1_HUMAN (683-1083): 1.54e-47: 188: 32.60
+	Hs
		778724 PRS7_HUMAN (84-392): 1.22e-115: 345: 56.31		HUWE1_HUMAN (683-1083): 1.54e-47: 188: 32.60
+	Sc
		750998 PRS7_YEAST (84-391): 1.54e-111: 336: 54.87		TOM1_YEAST (683-1083): 1.41e-46: 185: 32.12
+	Sc
		917352 PRS8_YEAST (11-115): 7.27e-09: 59.3: 6.67		HUL5_YEAST (662-1083): 8.11e-75: 268: 39.07
+	Hs
		975445 PRS10_HUMAN (11-123): 7.15e-10: 62.4: 9.74		HUWE1_HUMAN (683-1083): 1.54e-47: 188: 32.60
+	Sc
		1033875 PRS8_YEAST (11-115): 7.27e-09: 59.3: 6.67		TOM1_YEAST (683-1083): 1.41e-46: 185: 32.12