HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: EPHB1 (P54762)
Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
Gene: EPHB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	18034775, 23118026
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cbl_N~fn3, Cbl_N2~fn3, Cbl_N3~fn3
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045121 - membrane raft
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 984
+	Hs
		610245 CBL_HUMAN (1-906): 0: 917: 100.00		EPHA8_HUMAN (19-981): 0: 1061: 51.78
+	Hs
		610244 CBL_HUMAN (1-906): 0: 917: 100.00		EPHA2_HUMAN (17-978): 0: 1032: 46.58
+	Hs
		665361 CBLC_HUMAN (42-504): 0: 620: 42.07		EPHA2_HUMAN (17-978): 0: 1032: 46.58
+	Hs
		610252 CBL_HUMAN (1-906): 0: 917: 100.00		UFO_HUMAN (131-963): 1.83e-174: 532: 23.30
+	Hs
		435537 CBL_HUMAN (1-906): 0: 917: 100.00		IGF1R_HUMAN (390-883): 2.15e-141: 458: 30.71
+	Hs
		665647 ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25		EPHB2_HUMAN (19-981): 0: 1198: 73.76
+	Hs
		442780 CBL_HUMAN (1-906): 0: 917: 100.00		HCK_HUMAN (579-879): 7.25e-65: 229: 40.07
+	Hs
		412013 CBL_HUMAN (1-906): 0: 917: 100.00		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Mm
		411917 CBL_MOUSE (1-906): 0: 888: 91.59		LCK_MOUSE (577-879): 1.39e-64: 228: 41.12
+	Mm
		610554 CBL_MOUSE (1-906): 0: 888: 91.59		FYN_MOUSE (613-871): 2.5e-64: 228: 43.46
+	Hs
		600594 OTOG_HUMAN (405-893): 1.88e-23: 109: 12.85		EPHA1_HUMAN (11-973): 0: 955: 41.76
+	Hs
		412170 CBLB_HUMAN (23-901): 0: 793: 46.65		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Rn
		1144046 CBLB_RAT (23-901): 0: 792: 46.98		FYN_RAT (613-871): 2.55e-64: 228: 43.46
+	Mm
		411924 CBLB_MOUSE (23-901): 0: 791: 45.98		LCK_MOUSE (577-879): 1.39e-64: 228: 41.12
+	Ce
		220228 Q6ABG8_CAEEL (43-510): 0: 662: 48.24		SRC2_CAEEL (598-894): 6.11e-68: 238: 40.74
+	Ce
		220219 Q19019_CAEEL (49-546): 0: 639: 44.12		SRC2_CAEEL (598-894): 6.11e-68: 238: 40.74
+	Hs
		412405 CBLC_HUMAN (42-504): 0: 620: 42.07		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Hs
		412362 MAGE1_HUMAN (527-872): 1.47e-14: 80.4: 12.36		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Rn
		94371 F1M9G7_RAT (544-894): 3.04e-09: 63.4: 11.58		INSR_RAT (338-495): 1.19e-09: 64.6: 15.64
+	Rn
		88607 D3ZGN7_RAT (600-884): 4.19e-09: 62.6: 10.53		INSR_RAT (338-495): 1.19e-09: 64.6: 15.64