HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: UBS3A (Q3V3E1)
Ubiquitin-associated and SH3 domain-containing protein A (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)
Gene: Ubash3a

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	27474268
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	UBA~UBA
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 624
+	Hs
		610317 CBL_HUMAN (1-913): 0: 894: 91.05		UBS3A_HUMAN (1-624): 0: 991: 78.40
+	Mm
		610620 CBL_MOUSE (1-913): 0: 923: 100.00		UBS3B_MOUSE (1-618): 0: 905: 45.68
+	Hs
		610459 CBL_HUMAN (1-913): 0: 894: 91.05		UBS3B_HUMAN (1-618): 0: 914: 46.00
+	Hs
		883333 CBLB_HUMAN (23-908): 0: 799: 45.92		UBS3A_HUMAN (1-624): 0: 991: 78.40
+	Mm
		610598 CBL_MOUSE (1-913): 0: 923: 100.00		GRB2_MOUSE (140-303): 3.25e-46: 164: 21.69
+	Hs
		610338 CBL_HUMAN (1-913): 0: 894: 91.05		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Hs
		610437 CBL_HUMAN (1-913): 0: 894: 91.05		Q6ICN0_HUMAN (140-303): 8.54e-45: 160: 21.69
+	Mm
		610595 CBL_MOUSE (1-913): 0: 923: 100.00		SRBS2_MOUSE (195-301): 2.79e-24: 110: 24.14
+	Mm
		610640 CBL_MOUSE (1-913): 0: 923: 100.00		GRAP_MOUSE (140-301): 7.4e-24: 101: 16.87
+	Mm
		610608 CBL_MOUSE (1-913): 0: 923: 100.00		SRBS1_MOUSE (242-300): 6.94e-19: 93.3: 38.98
+	Rn
		88774 D3ZV15_RAT (1-877): 0: 852: 96.24		GRB2_RAT (140-303): 7.91e-46: 163: 21.69
+	Hs
		235473 CBL_HUMAN (1-913): 0: 894: 91.05		VINEX_HUMAN (165-301): 1.05e-25: 114: 20.86
+	Hs
		610540 CBL_HUMAN (1-913): 0: 894: 91.05		CD2AP_HUMAN (170-340): 1.1e-25: 114: 20.57
+	Hs
		298949 CBL_HUMAN (1-913): 0: 894: 91.05		SRBS2_HUMAN (195-301): 1.5e-24: 111: 25.86
+	Hs
		610501 CBL_HUMAN (1-913): 0: 894: 91.05		SRBS1_HUMAN (189-301): 6.91e-24: 109: 27.97
+	Mm
		610651 CBL_MOUSE (1-913): 0: 923: 100.00		CD2AP_MOUSE (221-305): 1.69e-10: 66: 25.88
+	Mm
		82735 B9EKI5_MOUSE (23-908): 0: 816: 47.71		GRB2_MOUSE (140-303): 3.25e-46: 164: 21.69
+	Hs
		924539 CBLB_HUMAN (23-908): 0: 799: 45.92		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Hs
		235501 CBLB_HUMAN (23-908): 0: 799: 45.92		VINEX_HUMAN (165-301): 1.05e-25: 114: 20.86
+	Hs
		298976 CBLB_HUMAN (23-908): 0: 799: 45.92		SRBS2_HUMAN (195-301): 1.5e-24: 111: 25.86