HitPredict

Interactor 1: EGR1 (P18146)
Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24)
Gene: EGR1

Interactor 2: CD40L (P29965)
CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
Gene: CD40LG

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.50	0.549

Property	Details
Experiments	16393964, 19032775
Identification Methods	electrophoretic mobility supershift assay, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 261
+	Hs
		715434 EGR3_HUMAN (97-449): 1.2e-90: 285: 48.61		CD40L_HUMAN (1-261): 5.85e-116: 334: 100.00
+	Hs
		612926 EGR1_HUMAN (1-543): 2.35e-147: 436: 100.00		TNFL6_HUMAN (89-261): 6.66e-55: 179: 18.86
+	Hs
		377954 EGR1_HUMAN (1-543): 2.35e-147: 436: 100.00		TNFA_HUMAN (87-261): 1.97e-52: 172: 21.20
+	Mm
		204500 EGR2_MOUSE (80-425): 1.59e-96: 303: 42.53		TNF11_MOUSE (35-261): 7.51e-73: 226: 21.84
+	Hs
		378068 EGR4_HUMAN (333-428): 1.9e-35: 142: 75.00		TNFA_HUMAN (87-261): 1.97e-52: 172: 21.20