Protein: CD40L
CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]

Gene: CD40L, CD40LG
Organism: Homo sapiens
Interactions: 18
UniProt ID: P29965

Gene Ontology (top 5):
GO:0002637 - regulation of immunoglobulin production
GO:0005125 - cytokine activity
GO:0005164 - tumor necrosis factor receptor binding
GO:0005174 - CD40 receptor binding
GO:0005178 - integrin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

683203

TNR5
Tumor necrosis factor receptor superfamily member 5

3

20

Small-scale

0.827

High

715433

REL
Proto-oncogene c-Rel

2

15

Small-scale

0.584

High

612887

EGR1
Early growth response protein 1

2

5

Small-scale

0.549

High

715441

RN128
E3 ubiquitin-protein ligase RNF128

1

0

Small-scale

0.537

High

715432

PHB1
Prohibitin 1

1

1

Small-scale

0.501

High

687332

PTBP1
Polypyrimidine tract-binding protein 1

1

1

Small-scale

0.479

High

715434

EGR3
Early growth response protein 3

1

5

Small-scale

0.479

High

715435

TRAF2
TNF receptor-associated factor 2

1

9

Small-scale

0.479

High

715436

TRAF1
TNF receptor-associated factor 1

1

9

Small-scale

0.479

High

715438

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

Small-scale

0.479

High

715439

BIRC2
Baculoviral IAP repeat-containing protein 2

1

6

Small-scale

0.479

High

715437

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

15

Small-scale

0.470

High

366228

HPTR
Haptoglobin-related protein

1

0

Small-scale

0.458

High

384628

CRYAB
Alpha-crystallin B chain

1

0

Small-scale

0.458

High

387240

APOA1
Apolipoprotein A-I

1

0

Small-scale

0.458

High

473664

ITA5
Integrin alpha-5

1

0

Small-scale

0.458

High

715440

AKNA
Microtubule organization protein AKNA

1

0

Small-scale

0.458

High

340832

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

16

Small-scale

0.437

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025