HitPredict

Interactor 1: CDKA1 (P24100)
Cyclin-dependent kinase A-1 (CDKA;1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog A) (CDC2aAt)
Gene: CDKA-1

Interactor 2: CCA23 (Q38819)
Cyclin-A2-3 (Cyc3c-At) (Cyclin-3c) (G2/mitotic-specific cyclin-A2-3) (CycA2;3)
Gene: CYCA2-3

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	20407024, 16415207
Identification Methods	protein complementation assay, two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0010389 - regulation of G2/M transition of mitotic cell cycle GO:0010444 - guard mother cell differentiation and 1 others more... GO:0042023 - DNA endoreduplication
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 294 At			1 450
+	At
		621691 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA24_ARATH (1-450): 9.86e-128: 379: 63.83
+	At
		621662 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA21_ARATH (8-450): 1.36e-122: 365: 46.55
+	At
		621653 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA22_ARATH (14-450): 1.66e-121: 362: 44.30
+	Hs
		625350 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNA1_HUMAN (18-446): 9.81e-117: 351: 31.05
+	At
		621690 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA11_ARATH (19-450): 6.23e-120: 359: 39.04
+	Hs
		590125 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNA2_HUMAN (5-447): 2.31e-112: 339: 31.40
+	Hs
		538471 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNB1_HUMAN (18-441): 2.34e-111: 336: 28.61
+	Hs
		590162 CDK3_HUMAN (1-294): 1.39e-146: 415: 68.03		CCNA2_HUMAN (5-447): 2.31e-112: 339: 31.40
+	Hs
		538521 CDK3_HUMAN (1-294): 1.39e-146: 415: 68.03		CCNB1_HUMAN (18-441): 2.34e-111: 336: 28.61
+	At
		621689 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA32_ARATH (80-450): 5.47e-114: 341: 42.09
+	At
		621697 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA31_ARATH (116-447): 2.38e-113: 339: 47.15
+	At
		48929 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA33_ARATH (144-450): 4.14e-110: 329: 44.34
+	At
		621664 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCA34_ARATH (97-450): 1.3e-109: 329: 41.46
+	Mm
		956329 CDK2_MOUSE (1-293): 8.12e-140: 399: 58.36		CCNA1_MOUSE (21-447): 5.6e-112: 337: 30.73
+	At
		621661 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCB12_ARATH (26-448): 1.44e-105: 322: 26.76
+	Mm
		851183 CDK2_MOUSE (1-293): 8.12e-140: 399: 58.36		CCNA2_MOUSE (5-448): 4.96e-110: 332: 31.10
+	Hs
		303829 CDK2_HUMAN (1-293): 6.46e-149: 420: 67.92		CCNB2_HUMAN (59-441): 2.09e-101: 310: 30.57
+	At
		621704 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCB23_ARATH (4-446): 7.81e-103: 314: 24.66
+	At
		621721 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCB31_ARATH (49-447): 5.6e-101: 308: 26.25
+	At
		621643 CDKA1_ARATH (1-294): 6.8e-145: 410: 100.00		CCB11_ARATH (51-448): 3.2e-99: 305: 27.70