HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: RAD50 (Q92878)
DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)
Gene: RAD50

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22231403
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 1312
+	Hs
		625176 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MYH9_HUMAN (474-1226): 2.43e-26: 119: 10.19
+	Sc
		339911 CDK1_YEAST (1-288): 3.57e-132: 378: 62.12		SMC4_YEAST (3-1285): 1.44e-50: 198: 10.82
+	Hs
		625530 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MY18A_HUMAN (158-674): 1.53e-19: 97.7: 14.45
+	Hs
		625436 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		SMC1A_HUMAN (290-1274): 4.82e-19: 95.7: 11.17
+	Hs
		960130 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH15_HUMAN (414-1219): 6.81e-27: 121: 10.64
+	Hs
		625177 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MYH10_HUMAN (44-596): 1.31e-16: 88.3: 13.20
+	Hs
		522604 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH7_HUMAN (524-1249): 1.05e-24: 114: 10.81
+	Hs
		528368 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH6_HUMAN (524-1204): 1.26e-24: 114: 10.15
+	Hs
		960128 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH2_HUMAN (556-1225): 9.34e-25: 114: 11.92
+	Hs
		528401 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MYH8_HUMAN (41-622): 1.09e-14: 81.7: 9.42
+	Hs
		960129 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH13_HUMAN (524-1245): 6.07e-22: 105: 10.56
+	Hs
		551610 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71
+	Hs
		522542 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH1_HUMAN (785-1235): 3.81e-15: 83.3: 13.32
+	Hs
		528405 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH8_HUMAN (41-622): 1.09e-14: 81.7: 9.42
+	Hs
		502908 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		MYH3_HUMAN (785-1231): 2.95e-12: 74: 11.60
+	Hs
		724717 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		MYH9_HUMAN (474-1226): 2.43e-26: 119: 10.19
+	Hs
		414713 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71
+	Hs
		148286 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15
+	Hs
		725114 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		MYH10_HUMAN (44-596): 1.31e-16: 88.3: 13.20