HitPredict

Interactor 1: WIPF3 (A6NGB9)
WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog)
Gene: WIPF3

Interactor 2: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 483 Hs			1 380
+	Hs
		209127 WIPF2_HUMAN (31-460): 3.17e-21: 98: 27.35		NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00
+	Hs
		166030 SYNJ2_HUMAN (5-430): 6.29e-22: 101: 16.34		NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24
+	Hs
		62640 WIPF3_HUMAN (33-483): 2.9e-22: 101: 100.00		NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24
+	Hs
		557748 WIPF2_HUMAN (31-460): 3.17e-21: 98: 27.35		NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24
+	Hs
		655524 MYO16_HUMAN (15-441): 1.5e-27: 119: 17.02		P85A_HUMAN (166-379): 4.05e-24: 106: 16.36
+	Hs
		412433 MYO16_HUMAN (15-441): 1.5e-27: 119: 17.02		FYN_HUMAN (7-137): 2.1e-23: 103: 20.30
+	Hs
		166056 SYNJ2_HUMAN (5-430): 6.29e-22: 101: 16.34		ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31
+	Hs
		62648 WIPF3_HUMAN (33-483): 2.9e-22: 101: 100.00		ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31
+	Hs
		1257321 WIPF2_HUMAN (31-460): 3.17e-21: 98: 27.35		ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31
+	Hs
		166032 SYNJ2_HUMAN (5-430): 6.29e-22: 101: 16.34		P85A_HUMAN (166-379): 4.05e-24: 106: 16.36
+	Hs
		166024 SYNJ2_HUMAN (5-430): 6.29e-22: 101: 16.34		FYN_HUMAN (7-137): 2.1e-23: 103: 20.30
+	Hs
		166049 SYNJ2_HUMAN (5-430): 6.29e-22: 101: 16.34		ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23
+	Hs
		62646 WIPF3_HUMAN (33-483): 2.9e-22: 101: 100.00		ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23
+	Hs
		166042 SYNJ2_HUMAN (5-430): 6.29e-22: 101: 16.34		GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81
+	Hs
		62643 WIPF3_HUMAN (33-483): 2.9e-22: 101: 100.00		GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81
+	Hs
		924473 MAP1A_HUMAN (3-454): 1.32e-21: 101: 13.27		GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81
+	Hs
		166055 SYNJ2_HUMAN (5-430): 6.29e-22: 101: 16.34		SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35
+	Hs
		924724 WIPF2_HUMAN (31-460): 3.17e-21: 98: 27.35		GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81
+	Hs
		1257317 WIPF2_HUMAN (31-460): 3.17e-21: 98: 27.35		SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35
+	Ce
		666227 SOS_CAEEL (67-431): 1.35e-20: 97.6: 13.12		SEM5_CAEEL (204-364): 4.9e-16: 78.6: 30.68