HitPredict

Interactor 1: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Interactor 2: KI67 (P46013)
Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)
Gene: MKI67

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26949251
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 808 Hs			1 3256
+	Hs
		801025 MCM2_HUMAN (10-721): 0: 707: 30.62		KI67_HUMAN (1-3256): 0: 1046: 100.00
+	Hs
		801141 MCM6_HUMAN (2-800): 0: 688: 26.50		KI67_HUMAN (1-3256): 0: 1046: 100.00
+	Hs
		708574 MCM5_HUMAN (9-713): 0: 685: 28.92		KI67_HUMAN (1-3256): 0: 1046: 100.00
+	Hs
		627208 MCM3_HUMAN (1-808): 0: 944: 100.00		MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59
+	Hs
		708394 MCM4_HUMAN (9-739): 0: 661: 28.03		MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59
+	Hs
		708834 MCM7_HUMAN (10-669): 0: 650: 31.62		MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59
+	Hs
		832603 MCM2_HUMAN (10-721): 0: 707: 30.62		MUC16_HUMAN (48-2581): 3.63e-63: 244: 8.34
+	Hs
		832607 MCM2_HUMAN (10-721): 0: 707: 30.62		TITIN_HUMAN (52-1221): 1.55e-13: 80: 7.85
+	Hs
		1055658 MCM6_HUMAN (2-800): 0: 688: 26.50		SRRM2_HUMAN (1748-3241): 1.64e-18: 96: 8.53