HitPredict

Interactor 1: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Interactor 2: SMCA4 (P51532)
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
Gene: SMARCA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~Bromodomain
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0070577 - lysine-acetylated histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 801 Hs			1 1647
+	Hs
		631379 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		SMCA2_HUMAN (1-1647): 0: 980: 71.69
+	Hs
		846977 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		SMCA4_HUMAN (1-1647): 0: 1105: 100.00
+	Hs
		846993 BRDT_HUMAN (48-763): 4.45e-106: 349: 45.39		SMCA4_HUMAN (1-1647): 0: 1105: 100.00
+	Hs
		846778 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		SMCA2_HUMAN (1-1647): 0: 980: 71.69
+	Hs
		229311 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		SMCA5_HUMAN (626-1631): 0: 835: 27.41
+	Hs
		631352 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		SMCA1_HUMAN (639-1619): 0: 832: 28.82
+	Hs
		631426 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		CHD4_HUMAN (482-1630): 0: 722: 23.79
+	Hs
		631414 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		CHD3_HUMAN (300-1646): 0: 711: 20.80
+	Hs
		631598 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		CHD8_HUMAN (13-1523): 0: 711: 21.11
+	Hs
		229407 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		SMCA5_HUMAN (626-1631): 0: 835: 27.41
+	Hs
		658677 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		SMCA1_HUMAN (639-1619): 0: 832: 28.82
+	Hs
		229252 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		SMCA5_HUMAN (626-1631): 0: 835: 27.41
+	Hs
		1059625 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		CHD4_HUMAN (482-1630): 0: 722: 23.79
+	Hs
		151415 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		CHD1_HUMAN (355-1641): 0: 713: 23.83
+	Hs
		1067151 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		CHD8_HUMAN (13-1523): 0: 711: 21.11
+	Hs
		1066982 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		CHD9_HUMAN (67-1534): 0: 702: 20.82
+	Hs
		1123395 BRDT_HUMAN (48-763): 4.45e-106: 349: 45.39		CHD8_HUMAN (13-1523): 0: 711: 21.11
+	Hs
		151361 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		CHD1_HUMAN (355-1641): 0: 713: 23.83
+	Hs
		151464 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		CHD2_HUMAN (343-1449): 0: 682: 26.93
+	Hs
		1067158 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		HELLS_HUMAN (683-1234): 1.22e-106: 362: 36.56