HitPredict

Interactor 1: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	26496610, 31753913, 30554943
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 801 Hs			1 1437
+	Hs
		1067123 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		NSD3_HUMAN (1-1437): 0: 1169: 100.00
+	Hs
		1123391 BRDT_HUMAN (48-763): 4.45e-106: 349: 45.39		NSD3_HUMAN (1-1437): 0: 1169: 100.00
+	Hs
		331723 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		331815 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Mm
		1207357 BRD4_MOUSE (26-777): 8.44e-101: 342: 45.70		NSD2_MOUSE (140-1416): 0: 825: 45.08
+	Hs
		243764 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		631553 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		631594 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Hs
		631536 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		EZH1_HUMAN (1076-1270): 4.39e-59: 220: 30.24
+	Hs
		631440 BRD2_HUMAN (1-773): 1.09e-171: 517: 100.00		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		1067098 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		1067147 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Hs
		1066975 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		244155 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		244797 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		244896 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		SETD2_HUMAN (1004-1320): 1.62e-59: 228: 32.18
+	Hs
		244495 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		975255 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		1067099 BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56		NSD1_HUMAN (91-724): 2.53e-28: 126: 15.30
+	Hs
		244315 BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13