HitPredict

Interactor 1: PROF (P25843)
Profilin (Protein chickadee)
Gene: chic

Interactor 2: ENA (Q8T4F7)
Protein enabled
Gene: ENA

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	10220404, 19052223, 31740789
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton GO:0007015 - actin filament organization GO:0007300 - ovarian nurse cell to oocyte transport GO:0007391 - dorsal closure GO:0051491 - positive regulation of filopodium assembly
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 126 Dm			1 980
+	Hs
		430098 PROF1_HUMAN (3-126): 1.89e-38: 128: 20.71		VASP_HUMAN (298-634): 5.11e-25: 110: 23.89
+	Mm
		936836 PROF2_MOUSE (3-126): 1.28e-33: 115: 20.71		VASP_MOUSE (298-630): 2.07e-26: 114: 24.18
+	Hs
		714941 PROF2_HUMAN (3-126): 1.79e-33: 115: 20.71		VASP_HUMAN (298-634): 5.11e-25: 110: 23.89
+	Hs
		430264 PROF1_HUMAN (3-126): 1.89e-38: 128: 20.71		ENAH_HUMAN (651-979): 1.3e-13: 77: 25.97
+	Hs
		430372 PROF1_HUMAN (3-126): 1.89e-38: 128: 20.71		EVL_HUMAN (687-978): 3.78e-11: 68.2: 23.08
+	Mm
		923936 PROF1_MOUSE (3-126): 1.31e-36: 123: 19.29		PCLO_MOUSE (371-962): 1.27e-11: 71.3: 9.49
+	Hs
		714977 PROF2_HUMAN (3-126): 1.79e-33: 115: 20.71		ENAH_HUMAN (651-979): 1.3e-13: 77: 25.97
+	Mm
		923919 PROF1_MOUSE (3-126): 1.31e-36: 123: 19.29		ENAH_MOUSE (515-979): 1.53e-09: 63.9: 16.53
+	Mm
		1337493 PROF2_MOUSE (3-126): 1.28e-33: 115: 20.71		PCLO_MOUSE (371-962): 1.27e-11: 71.3: 9.49
+	Hs
		715013 PROF2_HUMAN (3-126): 1.79e-33: 115: 20.71		EVL_HUMAN (687-978): 3.78e-11: 68.2: 23.08
+	Mm
		975407 PROF2_MOUSE (3-126): 1.28e-33: 115: 20.71		ENAH_MOUSE (515-979): 1.53e-09: 63.9: 16.53