HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: Q9UQC1 (Q9UQC1)
Heat shock protein 72
Gene: HSP70-1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 151
+	Hs
		639682 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		503471 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Mm
		926175 IKBA_MOUSE (1-317): 2.2e-78: 243: 91.17		HSP7C_MOUSE (1-150): 6.81e-76: 239: 87.33
+	Hs
		121603 IKBE_HUMAN (3-315): 1.28e-74: 239: 32.10		Q9UQC1_HUMAN (1-151): 8.55e-83: 241: 100.00
+	Hs
		121572 IKBE_HUMAN (3-315): 1.28e-74: 239: 32.10		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		121564 IKBE_HUMAN (3-315): 1.28e-74: 239: 32.10		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Mm
		638457 NFKB1_MOUSE (70-302): 5.46e-66: 224: 38.98		HS71A_MOUSE (1-150): 9.78e-78: 243: 95.33
+	Dr
		1157472 MIB1_DANRE (1-299): 1.46e-66: 226: 24.63		Q6NYR4_DANRE (1-150): 3.94e-75: 237: 87.33
+	Hs
		564057 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		HSP76_HUMAN (1-150): 3.19e-78: 245: 85.33
+	Hs
		961447 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		Q9UQC1_HUMAN (1-151): 8.55e-83: 241: 100.00
+	Hs
		713945 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		503906 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		483759 ANK2_HUMAN (118-315): 9.61e-41: 153: 23.50		HS71A_HUMAN (1-150): 1.18e-77: 243: 100.00
+	Hs
		503916 ANK2_HUMAN (118-315): 9.61e-41: 153: 23.50		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		564048 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		HSP76_HUMAN (1-150): 3.19e-78: 245: 85.33
+	Hs
		564185 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		HSP76_HUMAN (1-150): 3.19e-78: 245: 85.33
+	Hs
		503777 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		504758 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		HSP7C_HUMAN (1-150): 6.81e-76: 239: 87.33
+	Hs
		714021 ANKK1_HUMAN (152-310): 1.44e-32: 129: 21.38		HS71L_HUMAN (1-150): 2.61e-76: 240: 91.33
+	Hs
		564002 BCL3_HUMAN (26-234): 3e-29: 118: 24.76		HSP76_HUMAN (1-150): 3.19e-78: 245: 85.33