HitPredict

Interactor 1: DDX6 (P26196)
Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK)
Gene: DDX6

Interactor 2: IF4A2 (Q14240)
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Gene: EIF4A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DEAD~DEAD, DEAD~Helicase_C, Helicase_C~Helicase_C
Common GO terms	GO:0003723 - RNA binding GO:0003724 - RNA helicase activity GO:0004386 - helicase activity GO:0005524 - ATP binding GO:0005829 - cytosol and 1 others more... GO:0016887 - ATP hydrolysis activity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 483 Hs			1 407
+	Hs
		757526 IF4A3_HUMAN (58-464): 7.79e-170: 486: 35.70		IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88
+	Hs
		640391 DDX6_HUMAN (1-483): 4.05e-151: 441: 100.00		IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88
+	Hs
		757701 IF4A3_HUMAN (58-464): 7.79e-170: 486: 35.70		DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20
+	Hs
		133911 IF4A3_HUMAN (58-464): 7.79e-170: 486: 35.70		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51
+	Hs
		757491 IF4A3_HUMAN (58-464): 7.79e-170: 486: 35.70		IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65
+	Hs
		133951 DDX3X_HUMAN (8-473): 3.18e-131: 396: 25.26		IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88
+	Sc
		624206 DBP1_YEAST (14-464): 1.64e-154: 454: 25.05		DBP1_YEAST (4-406): 3.09e-127: 382: 31.52
+	Hs
		640569 DDX6_HUMAN (1-483): 4.05e-151: 441: 100.00		DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20
+	Hs
		1271612 DDX17_HUMAN (24-467): 7.5e-145: 433: 27.31		DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20
+	Hs
		571538 DDX17_HUMAN (24-467): 7.5e-145: 433: 27.31		DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30
+	Hs
		133887 DDX6_HUMAN (1-483): 4.05e-151: 441: 100.00		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51
+	Hs
		134146 DDX17_HUMAN (24-467): 7.5e-145: 433: 27.31		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51
+	Hs
		571300 DDX5_HUMAN (15-467): 1.7e-142: 423: 25.70		DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30
+	Hs
		133874 DDX5_HUMAN (15-467): 1.7e-142: 423: 25.70		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51
+	Sc
		624023 DBP2_YEAST (30-471): 9.23e-141: 417: 25.89		DBP2_YEAST (22-405): 1.21e-131: 390: 32.65
+	Zm
		82185 B8A2Z7_MAIZE (62-469): 4.81e-136: 404: 69.61		B8A2Z7_MAIZE (33-407): 7.08e-88: 277: 38.93