HitPredict

Interactor 1: HMGB2 (P26583)
High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Gene: HMGB2

Interactor 2: Q96I87 (Q96I87)
Homeobox-containing protein PKNOX1 (PBX/knotted 1 homeobox 1)
Gene: PKNOX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 209 Hs			1 436
+	Hs
		643279 HMGB2_HUMAN (1-187): 3.05e-41: 140: 100.00		PKNX1_HUMAN (1-436): 1.71e-128: 380: 100.00
+	Hs
		154473 SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83		MEIS2_HUMAN (3-413): 2.47e-93: 291: 31.62
+	Dm
		115533 M9PFG6_DROME (7-95): 6.73e-26: 104: 20.23		HTH_DROME (10-367): 8.04e-79: 254: 30.47
+	Hs
		773201 CIC_HUMAN (3-100): 1.66e-11: 64.7: 22.45		PBX3_HUMAN (29-428): 1.13e-68: 226: 15.98
+	Hs
		773099 SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83		PBX2_HUMAN (65-402): 5.06e-52: 182: 14.49
+	Hs
		818437 SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83		PBX4_HUMAN (65-418): 6.59e-52: 180: 14.37
+	Hs
		773088 CIC_HUMAN (3-100): 1.66e-11: 64.7: 22.45		PBX1_HUMAN (30-427): 4.01e-55: 190: 15.09
+	Hs
		773134 CIC_HUMAN (3-100): 1.66e-11: 64.7: 22.45		PBX2_HUMAN (65-402): 5.06e-52: 182: 14.49
+	Hs
		782197 SOX3_HUMAN (5-84): 5.39e-24: 100: 22.50		TGIF1_HUMAN (212-377): 2.28e-37: 142: 23.84
+	Ce
		1095167 EGL13_CAEEL (4-96): 1.11e-24: 102: 20.43		UNC62_CAEEL (171-404): 6.7e-27: 115: 24.17
+	Hs
		1300932 CIC_HUMAN (3-100): 1.66e-11: 64.7: 22.45		TGIF2_HUMAN (250-322): 3.33e-13: 70.9: 46.15