HitPredict

Interactor 1: IL3RA (P26951)
Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (CD antigen CD123)
Gene: IL3RA

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	7523859, 17474147
Identification Methods	affinity chromatography technology, peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 378 Hs			1 217
+	Hs
		924483 IL5RA_HUMAN (1-375): 9.47e-63: 208: 25.18		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		557611 IL3RA_HUMAN (18-378): 7.15e-106: 317: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		412028 IL3RA_HUMAN (18-378): 7.15e-106: 317: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		500956 GHR_HUMAN (89-347): 8.09e-42: 156: 14.78		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924590 EPHA7_HUMAN (66-284): 7.33e-40: 152: 13.50		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		682260 IL2RG_HUMAN (90-368): 1.5e-41: 151: 17.41		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		645942 CNTFR_HUMAN (41-303): 1.14e-40: 149: 14.49		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		540268 EPOR_MOUSE (102-363): 4.92e-39: 147: 18.35		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		872610 EPHB1_HUMAN (42-327): 2.1e-38: 148: 13.10		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		548629 PRLR_HUMAN (101-353): 2.02e-58: 201: 16.79		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		560471 PRLR_HUMAN (101-353): 2.02e-58: 201: 16.79		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18
+	Hs
		500941 GHR_HUMAN (89-347): 8.09e-42: 156: 14.78		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		789068 EPHA7_HUMAN (66-284): 7.33e-40: 152: 13.50		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		557612 CNTFR_HUMAN (41-303): 1.14e-40: 149: 14.49		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337354 CNTFR_HUMAN (41-303): 1.14e-40: 149: 14.49		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		557644 EPHB1_HUMAN (42-327): 2.1e-38: 148: 13.10		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		412029 CNTFR_HUMAN (41-303): 1.14e-40: 149: 14.49		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433772 EPHA7_HUMAN (66-284): 7.33e-40: 152: 13.50		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		433567 EPOR_HUMAN (102-363): 4.2e-39: 147: 18.21		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Mm
		540265 EPOR_MOUSE (102-363): 4.92e-39: 147: 18.35		LYN_MOUSE (129-215): 2.66e-11: 64.2: 22.47