HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	35271311, 36931259, 15161933, 10664457
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 2549
+	Hs
		787440 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		787451 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		683184 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		683882 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		787460 1433F_HUMAN (2-242): 7.16e-106: 307: 71.43		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		787438 1433G_HUMAN (1-242): 5.48e-105: 305: 70.33		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		927004 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		ATM_HUMAN (387-2548): 0: 894: 14.98
+	Hs
		683847 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		TRRAP_HUMAN (925-2548): 0: 720: 15.53
+	At
		788647 14333_ARATH (3-243): 8e-143: 401: 61.63		ATM_ARATH (401-2548): 0: 704: 13.98
+	Hs
		646792 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Hs
		926917 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Hs
		683261 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Hs
		905297 1433G_HUMAN (1-242): 5.48e-105: 305: 70.33		TRRAP_HUMAN (925-2548): 0: 720: 15.53
+	Hs
		904439 1433G_HUMAN (1-242): 5.48e-105: 305: 70.33		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Hs
		982077 1433F_HUMAN (2-242): 7.16e-106: 307: 71.43		Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12
+	Hs
		904645 1433G_HUMAN (1-242): 5.48e-105: 305: 70.33		Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12
+	Hs
		647159 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17
+	Hs
		927364 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17
+	Dm
		664613 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		Q7K3H0_DROME (1898-2419): 8.48e-26: 119: 19.33