HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: CRTC1 (Q6UUV9)
CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)
Gene: CRTC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	33961781, 35271311, 36931259, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 634
+	Hs
		909700 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CRTC1_HUMAN (1-634): 1.78e-64: 225: 100.00
+	Hs
		927185 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		CRTC1_HUMAN (1-634): 1.78e-64: 225: 100.00
+	Rn
		910356 1433E_RAT (2-243): 1.31e-144: 406: 63.53		CRTC1_RAT (1-634): 9.55e-58: 207: 83.78
+	Mm
		910268 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		CRTC1_MOUSE (1-634): 1.01e-55: 201: 83.31
+	Hs
		909630 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CRTC2_HUMAN (2-634): 2.62e-31: 131: 33.00
+	Hs
		646948 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		CRTC2_HUMAN (2-634): 2.62e-31: 131: 33.00
+	Hs
		927110 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		CRTC2_HUMAN (2-634): 2.62e-31: 131: 33.00
+	Hs
		909666 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		TENS2_HUMAN (213-596): 1.04e-26: 118: 16.83
+	Hs
		909699 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CRTC3_HUMAN (2-634): 2.61e-22: 103: 27.40
+	Hs
		297821 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		K0754_HUMAN (5-379): 5.85e-21: 100: 9.16
+	Hs
		647017 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		CRTC3_HUMAN (2-634): 2.61e-22: 103: 27.40
+	Hs
		927184 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		CRTC3_HUMAN (2-634): 2.61e-22: 103: 27.40
+	Hs
		297824 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		K0754_HUMAN (5-379): 5.85e-21: 100: 9.16
+	Hs
		909712 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		OTOG_HUMAN (36-517): 3.96e-14: 78.3: 11.22
+	Hs
		909937 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CIC_HUMAN (31-553): 6.06e-12: 71.4: 11.41
+	Hs
		647025 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		OTOG_HUMAN (36-517): 3.96e-14: 78.3: 11.22
+	Hs
		927196 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		OTOG_HUMAN (36-517): 3.96e-14: 78.3: 11.22
+	Hs
		909862 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ATX2L_HUMAN (96-583): 1.09e-10: 67.2: 9.84
+	Hs
		647206 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		CIC_HUMAN (31-553): 6.06e-12: 71.4: 11.41
+	Hs
		647144 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ATX2L_HUMAN (96-583): 1.09e-10: 67.2: 9.84