Protein: RPOB
DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (EC 2.7.7.6) (RNA polymerase subunit beta) (Transcriptase subunit beta)

Gene: RPOB
Organism: Escherichia coli K-12
Interactions: 101
UniProt ID: P0A8V2

Gene Ontology (top 5):
GO:0000345 - cytosolic DNA-directed RNA polymerase complex
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

495796

RPOC
DNA-directed RNA polymerase subunit beta'

6

20

Small-scale

0.946

High

365815

RPOD
RNA polymerase sigma factor RpoD

5

12

Small-scale

0.919

High

395145

UVRD
DNA helicase II

3

5

Small-scale

0.847

High

495904

NUSA
Transcription termination/antitermination protein NusA

3

0

High-throughput

0.804

High

495935

RAPA
RNA polymerase-associated protein RapA

2

4

High-throughput

0.803

High

494593

RPOA
DNA-directed RNA polymerase subunit alpha

2

4

High-throughput

0.789

High

495905

NUSG
Transcription termination/antitermination protein NusG

2

1

High-throughput

0.789

High

495908

RPOH
RNA polymerase sigma factor RpoH

2

12

High-throughput

0.789

High

495921

RP54
RNA polymerase sigma-54 factor

2

1

High-throughput

0.789

High

495915

RPOS
RNA polymerase sigma factor RpoS

2

12

Small-scale

0.783

High

495906

RHO
Transcription termination factor Rho

2

3

High-throughput

0.759

High

494660

RPOZ
DNA-directed RNA polymerase subunit omega

2

0

High-throughput

0.749

High

495932

TORR
TorCAD operon transcriptional regulatory protein TorR

2

0

High-throughput

0.720

High

495903

FLIA
RNA polymerase sigma factor FliA

1

12

High-throughput

0.691

High

495909

RPOE
ECF RNA polymerase sigma-E factor

1

3

High-throughput

0.691

High

495923

RHLE
ATP-dependent RNA helicase RhlE

1

2

High-throughput

0.691

High

495936

RL2
Large ribosomal subunit protein uL2

3

2

High-throughput

0.657

High

495917

FECI
Ferric citrate uptake sigma factor FecI

1

0

High-throughput

0.656

High

490805

GREA
Transcription elongation factor GreA

1

1

High-throughput

0.625

High

493860

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.625

High

495924

GREB
Transcription elongation factor GreB

1

1

High-throughput

0.625

High

495925

MFD
Transcription-repair-coupling factor

1

6

Small-scale

0.590

High

492467

RL7
Large ribosomal subunit protein bL12

2

1

High-throughput

0.588

High

493211

RS10
Small ribosomal subunit protein uS10

2

3

High-throughput

0.588

High

495882

G3P1
Glyceraldehyde-3-phosphate dehydrogenase A

2

1

High-throughput

0.588

High

495912

EFTU1
Elongation factor Tu 1

2

5

High-throughput

0.588

High

495889

RLUC
Ribosomal large subunit pseudouridine synthase C

2

0

High-throughput

0.585

High

382559

RS6
Small ribosomal subunit protein bS6

2

0

High-throughput

0.563

High

444283

TOP1
DNA topoisomerase 1

2

0

High-throughput

0.563

High

493081

RL33
Large ribosomal subunit protein bL33

2

0

High-throughput

0.563

High

493603

RS20
Small ribosomal subunit protein bS20

2

0

High-throughput

0.563

High

495897

DBHA
DNA-binding protein HU-alpha

2

0

High-throughput

0.563

High

495907

RS14
Small ribosomal subunit protein uS14

2

0

High-throughput

0.563

High

495914

SECA
Protein translocase subunit SecA

2

0

High-throughput

0.563

High

495937

RL4
Large ribosomal subunit protein uL4

2

0

High-throughput

0.563

High

495940

RS21
Small ribosomal subunit protein bS21

2

0

High-throughput

0.563

High

492207

PYRG
CTP synthase

1

1

High-throughput

0.536

High

495881

CSPE
Cold shock-like protein CspE

1

2

High-throughput

0.536

High

495887

CSPA
Cold shock protein CspA

1

2

High-throughput

0.536

High

495895

SDHA
Succinate dehydrogenase flavoprotein subunit

1

1

High-throughput

0.536

High

495927

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.536

High

495928

YEGD
Uncharacterized chaperone protein YegD

1

9

High-throughput

0.536

High

495900

CEDA
Cell division activator CedA

1

0

High-throughput

0.523

High

490636

FABA
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

1

0

High-throughput

0.513

High

494908

TIG
Trigger factor

1

0

High-throughput

0.513

High

495467

YBED
UPF0250 protein YbeD

1

0

High-throughput

0.513

High

495884

LDCI
Inducible lysine decarboxylase

1

0

High-throughput

0.513

High

495902

FKBX
FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.513

High

495919

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

High-throughput

0.513

High

495930

DPPF
Dipeptide transport ATP-binding protein DppF

1

0

High-throughput

0.513

High

495931

YDDE
Uncharacterized isomerase YddE

1

0

High-throughput

0.513

High

495933

USPG
Universal stress protein UP12

1

0

High-throughput

0.513

High

495951

NORV
Anaerobic nitric oxide reductase flavorubredoxin

1

0

High-throughput

0.513

High

495894

ELBB
Glyoxalase ElbB

1

0

High-throughput

0.493

High

495948

HSCC
Chaperone protein HscC

1

7

High-throughput

0.489

High

469900

USG
USG-1 protein

1

2

High-throughput

0.484

High

492423

RL11
Large ribosomal subunit protein uL11

1

3

High-throughput

0.484

High

494242

RS5
Small ribosomal subunit protein uS5

1

4

High-throughput

0.484

High

495644

SYK2
Lysine--tRNA ligase, heat inducible

1

2

High-throughput

0.484

High

495886

MREB
Cell shape-determining protein MreB

1

8

High-throughput

0.484

High

495892

ATPB
ATP synthase subunit beta

1

3

High-throughput

0.484

High

495893

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

1

9

High-throughput

0.484

High

495945

KDGR
HTH-type transcriptional regulator KdgR

1

5

High-throughput

0.479

High

365866

DPO1
DNA polymerase I

1

0

High-throughput

0.464

High

437528

TSAD
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.464

High

490867

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.464

High

494880

TGT
Queuine tRNA-ribosyltransferase

1

0

High-throughput

0.464

High

495125

TUSA
Sulfur carrier protein TusA

1

0

High-throughput

0.464

High

495883

CYSB
HTH-type transcriptional regulator CysB

1

0

High-throughput

0.464

High

495888

GLNB
Nitrogen regulatory protein P-II 1

1

0

High-throughput

0.464

High

495891

PSTB
Phosphate import ATP-binding protein PstB

1

0

High-throughput

0.464

High

495896

SSPA
Stringent starvation protein A

1

0

High-throughput

0.464

High

495898

HNS
DNA-binding protein H-NS

1

0

High-throughput

0.464

High

495911

IBPA
Small heat shock protein IbpA

1

0

High-throughput

0.464

High

495916

MUTL
DNA mismatch repair protein MutL

1

0

High-throughput

0.464

High

495918

YICC
Endoribonuclease YicC

1

0

High-throughput

0.464

High

495929

DCTR
HTH-type transcriptional regulator DctR

1

0

High-throughput

0.464

High

495939

RL22
Large ribosomal subunit protein uL22

1

0

High-throughput

0.464

High

495943

GNGF
Putative gluconeogenesis factor

1

0

High-throughput

0.464

High

495944

LDCA
Murein tetrapeptide carboxypeptidase

1

0

High-throughput

0.464

High

495553

TMAR
Pole-localizer protein TmaR

1

0

High-throughput

0.458

High

495899

MAOP
Macrodomain Ori protein

1

0

High-throughput

0.458

High

495946

YFFS
Uncharacterized protein YffS

1

0

High-throughput

0.458

High

495913

EFTU2
Elongation factor Tu 2

1

5

High-throughput

0.445

High

495885

YBHF
Probable multidrug ABC transporter ATP-binding protein YbhF

1

3

High-throughput

0.442

High

495910

SSB
Single-stranded DNA-binding protein

1

0

High-throughput

0.426

High

495922

RIBD
Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase

2

0

High-throughput

0.307

High

494775

SMG
Protein Smg

1

0

High-throughput

0.279

Low

495901

DMA
DNA adenine methylase

1

0

High-throughput

0.279

Low

495926

ADEC
Adenine deaminase

1

0

High-throughput

0.279

Low

495934

RATB
UPF0125 protein RatB

1

0

High-throughput

0.279

Low

495941

WCAK
Colanic acid biosynthesis protein WcaK

1

0

High-throughput

0.279

Low

495947

OMPL
Porin OmpL

1

0

High-throughput

0.279

Low

449903

CCA
Multifunctional CCA protein [Includes: CCA-adding enzyme

1

0

High-throughput

0.253

Low

495261

YACL
UPF0231 protein YacL

1

0

High-throughput

0.253

Low

495890

CYCA
D-serine/D-alanine/glycine transporter

1

0

High-throughput

0.253

Low

495920

RHSE
Putative protein RhsE

1

0

High-throughput

0.253

Low

495938

YIDE
Putative transport protein YidE

1

0

High-throughput

0.253

Low

495942

YAHO
Uncharacterized protein YahO

1

0

High-throughput

0.253

Low

495949

RSXC
Ion-translocating oxidoreductase complex subunit C

1

0

High-throughput

0.253

Low

495950

XDHD
Probable hypoxanthine oxidase XdhD

1

0

High-throughput

0.253

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025