HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: M3K2 (Q9Y2U5)
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
Gene: MAP3K2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.735

Property	Details
Experiments	33961781, 36931259, 26496610, 32707033, 36736316, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 619
+	Hs
		910191 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K2_HUMAN (1-619): 0: 590: 100.00
+	Hs
		909957 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	Hs
		647221 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	Hs
		909811 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		DCLK2_HUMAN (22-618): 6.33e-137: 419: 18.53
+	Mm
		910275 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		DCLK2_MOUSE (22-618): 9.25e-137: 418: 17.95
+	Hs
		647105 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		DCLK2_HUMAN (22-618): 6.33e-137: 419: 18.53
+	Hs
		166549 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		DCLK1_HUMAN (22-618): 1.67e-133: 409: 16.56
+	Hs
		166534 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		DCLK1_HUMAN (22-618): 1.67e-133: 409: 16.56
+	Mm
		910345 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		DCLK1_MOUSE (22-618): 3.7e-130: 401: 16.15
+	Hs
		166550 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		DCLK1_HUMAN (22-618): 1.67e-133: 409: 16.56
+	Hs
		910114 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		PAK5_HUMAN (4-617): 9.48e-130: 399: 20.21
+	Hs
		647344 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		PAK5_HUMAN (4-617): 9.48e-130: 399: 20.21
+	At
		965360 14332_ARATH (3-243): 8.65e-144: 404: 61.22		CIPKC_ARATH (336-618): 2.88e-129: 390: 26.67
+	At
		788672 14333_ARATH (3-243): 8e-143: 401: 61.63		CIPKC_ARATH (336-618): 2.88e-129: 390: 26.67
+	At
		1280891 14337_ARATH (2-243): 2.78e-142: 400: 60.32		CIPKC_ARATH (336-618): 2.88e-129: 390: 26.67
+	Hs
		926996 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		PAK1_HUMAN (96-617): 8.05e-126: 383: 23.83
+	Dm
		90534 1433E_DROME (2-242): 6.77e-143: 401: 65.02		E1JGN0_DROME (203-617): 2.5e-110: 358: 22.70
+	At
		788620 14333_ARATH (3-243): 8e-143: 401: 61.63		M3K2_ARATH (294-617): 3.89e-113: 354: 42.77
+	Hs
		909513 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		M3K1_HUMAN (351-613): 5.82e-51: 192: 42.13
+	Hs
		646860 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		M3K1_HUMAN (351-613): 5.82e-51: 192: 42.13