HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: RPGF2 (Q9Y4G8)
Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
Gene: RAPGEF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	36931259
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007264 - small GTPase-mediated signal transduction GO:0016020 - membrane GO:0032991 - protein-containing complex and 1 others more... GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1499
+	Hs
		910200 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		RPGF2_HUMAN (1-1499): 0: 1710: 100.00
+	Hs
		927702 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		RPGF2_HUMAN (1-1499): 0: 1710: 100.00
+	Hs
		683851 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		RPGF2_HUMAN (1-1499): 0: 1710: 100.00
+	Mm
		926845 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		RPGF2_MOUSE (1-1499): 0: 1644: 94.67
+	Hs
		909851 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		RPGF6_HUMAN (20-1499): 0: 1352: 63.43
+	Hs
		647134 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		RPGF6_HUMAN (20-1499): 0: 1352: 63.43
+	Hs
		927336 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		RPGF6_HUMAN (20-1499): 0: 1352: 63.43
+	Hs
		683569 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		RPGF6_HUMAN (20-1499): 0: 1352: 63.43
+	Hs
		684227 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		RPGF6_HUMAN (20-1499): 0: 1352: 63.43
+	Hs
		647081 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		GRP3_HUMAN (601-1243): 6.86e-137: 440: 14.43
+	Hs
		683335 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		RGRF1_HUMAN (277-952): 2.25e-132: 444: 18.05
+	Hs
		171544 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		RGL2_HUMAN (559-1220): 8.04e-123: 404: 14.37
+	Hs
		171537 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		RGL2_HUMAN (559-1220): 8.04e-123: 404: 14.37
+	Hs
		171538 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		RGL2_HUMAN (559-1220): 8.04e-123: 404: 14.37
+	Hs
		909770 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		RGPS2_HUMAN (700-1105): 3.12e-81: 281: 19.76
+	Hs
		647073 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		RGPS2_HUMAN (700-1105): 3.12e-81: 281: 19.76
+	Hs
		927257 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		RGPS2_HUMAN (700-1105): 3.12e-81: 281: 19.76
+	Hs
		683515 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		RGPS2_HUMAN (700-1105): 3.12e-81: 281: 19.76
+	Hs
		684179 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		RGPS2_HUMAN (700-1105): 3.12e-81: 281: 19.76
+	Mm
		926773 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		RGRF2_MOUSE (277-426): 2.6e-21: 103: 20.00