HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: KS6A6 (Q9UK32)
Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4)
Gene: RPS6KA6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 802 Hs			1 745
+	Hs
		648468 FGFR4_HUMAN (13-802): 0: 755: 100.00		KS6A3_HUMAN (2-745): 0: 807: 76.54
+	Hs
		641141 FGFR2_HUMAN (4-797): 0: 748: 56.44		KS6A3_HUMAN (2-745): 0: 807: 76.54
+	Hs
		648518 FGFR4_HUMAN (13-802): 0: 755: 100.00		KS6A1_HUMAN (2-743): 0: 787: 72.16
+	Hs
		641179 FGFR2_HUMAN (4-797): 0: 748: 56.44		KS6A1_HUMAN (2-743): 0: 787: 72.16
+	Hs
		650095 FGFR3_HUMAN (5-799): 0: 720: 61.07		KS6A3_HUMAN (2-745): 0: 807: 76.54
+	Hs
		541404 FGFR1_HUMAN (3-794): 0: 714: 54.76		KS6A3_HUMAN (2-745): 0: 807: 76.54
+	Hs
		541503 FGFR1_HUMAN (3-794): 0: 714: 54.76		KS6A1_HUMAN (2-743): 0: 787: 72.16
+	Rn
		1046850 FGFR1_RAT (3-794): 0: 706: 54.14		KS6A1_RAT (2-743): 0: 788: 72.16
+	Hs
		411615 NTRK1_HUMAN (135-751): 2.17e-160: 487: 26.53		KS6A3_HUMAN (2-745): 0: 807: 76.54
+	Hs
		411982 NTRK1_HUMAN (135-751): 2.17e-160: 487: 26.53		KS6A1_HUMAN (2-743): 0: 787: 72.16
+	Hs
		463929 RET_HUMAN (221-802): 2.72e-146: 459: 34.72		KS6A3_HUMAN (2-745): 0: 807: 76.54
+	Hs
		648436 FGFR4_HUMAN (13-802): 0: 755: 100.00		AKT1_HUMAN (417-729): 1.48e-117: 364: 24.23
+	Hs
		541360 FGFR1_HUMAN (3-794): 0: 714: 54.76		AKT1_HUMAN (417-729): 1.48e-117: 364: 24.23
+	Hs
		641178 FGFR2_HUMAN (4-797): 0: 748: 56.44		KS6A2_HUMAN (2-330): 3.31e-100: 326: 22.87
+	Hs
		541502 FGFR1_HUMAN (3-794): 0: 714: 54.76		KS6A2_HUMAN (2-330): 3.31e-100: 326: 22.87
+	Hs
		728251 EPHA7_HUMAN (4-781): 0: 605: 19.78		AKT1_HUMAN (417-729): 1.48e-117: 364: 24.23
+	Hs
		710085 EPHA2_HUMAN (4-789): 0: 587: 19.52		AKT1_HUMAN (417-729): 1.48e-117: 364: 24.23
+	Hs
		710254 EPHA2_HUMAN (4-789): 0: 587: 19.52		KS6A2_HUMAN (2-330): 3.31e-100: 326: 22.87