HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: MP2K4 (P45985)
Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK)
Gene: MAP2K4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37827155
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 399
+	Hs
		650467 RFA1_HUMAN (1-616): 0: 781: 100.00		AKT2_HUMAN (57-399): 3.9e-126: 374: 20.86
+	Hs
		650466 RFA1_HUMAN (1-616): 0: 781: 100.00		AKT1_HUMAN (74-399): 9.1e-126: 373: 19.22
+	Hs
		568552 RFA1_HUMAN (1-616): 0: 781: 100.00		KAPCA_HUMAN (91-399): 1.73e-121: 357: 18.41
+	Hs
		625131 RFA1_HUMAN (1-616): 0: 781: 100.00		CDK2_HUMAN (99-378): 8.94e-122: 356: 22.62
+	Hs
		650606 RFA1_HUMAN (1-616): 0: 781: 100.00		MP2K3_HUMAN (22-387): 5.5e-121: 356: 46.72
+	Hs
		652744 RFA1_HUMAN (1-616): 0: 781: 100.00		STK24_HUMAN (72-387): 1.03e-99: 305: 32.81
+	Hs
		652477 RFA1_HUMAN (1-616): 0: 781: 100.00		STK26_HUMAN (98-388): 2.17e-98: 301: 32.88
+	Hs
		650522 RFA1_HUMAN (1-616): 0: 781: 100.00		MP2K2_HUMAN (100-393): 3.95e-62: 206: 37.24
+	Hs
		650999 RFA1_HUMAN (1-616): 0: 781: 100.00		MP2K1_HUMAN (100-393): 1.72e-60: 202: 36.20
+	Zm
		2187 A0A1D6EZA2_MAIZE (83-505): 1.89e-78: 267: 14.57		A0A0B4J3D8_MAIZE (92-369): 2.7e-113: 340: 21.91