HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: RHOH (Q15669)
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
Gene: RHOH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0030217 - T cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 191
+	Hs
		436167 P85A_HUMAN (1-724): 0: 596: 100.00		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		655304 P85A_HUMAN (1-724): 0: 596: 100.00		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		655307 P85A_HUMAN (1-724): 0: 596: 100.00		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		564419 P85A_HUMAN (1-724): 0: 596: 100.00		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Mm
		643072 P85A_MOUSE (1-724): 0: 592: 95.99		RAC1_MOUSE (2-191): 2.63e-75: 226: 39.09
+	Hs
		655295 P85A_HUMAN (1-724): 0: 596: 100.00		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		545215 P85A_HUMAN (1-724): 0: 596: 100.00		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		655294 P85A_HUMAN (1-724): 0: 596: 100.00		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Hs
		655316 P85A_HUMAN (1-724): 0: 596: 100.00		RHOG_HUMAN (2-191): 2.32e-71: 216: 37.56
+	Hs
		655297 P85A_HUMAN (1-724): 0: 596: 100.00		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		129298 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOH_HUMAN (1-191): 2.74e-95: 276: 100.00
+	Hs
		129267 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		129270 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		129193 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Hs
		129260 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		129190 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		129259 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Hs
		129275 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOG_HUMAN (2-191): 2.32e-71: 216: 37.56
+	Hs
		129262 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		564631 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49