HitPredict

Interactor 1: S10A1 (P23297)
Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)
Gene: S100A1

Interactor 2: S10A2 (P29034)
Protein S100-A2 (CAN19) (Protein S-100L) (S100 calcium-binding protein A2)
Gene: S100A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.901

Property	Details
Experiments	25416956, 32296183, 31515488, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	EF-hand_1~S_100, S_100~S_100
Common GO terms	GO:0005509 - calcium ion binding GO:0048306 - calcium-dependent protein binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 94 Hs			1 98
+	Hs
		1214472 Q5T7Y6_HUMAN (1-94): 9.45e-43: 137: 100.00		Q5T7Y6_HUMAN (2-91): 3.16e-40: 131: 52.22
+	Hs
		682510 Q5T7Y6_HUMAN (1-94): 9.45e-43: 137: 100.00		S100P_HUMAN (4-92): 1.21e-35: 118: 42.70
+	Mm
		450158 S10A1_MOUSE (1-94): 8.83e-38: 123: 92.55		S10A4_MOUSE (2-97): 3.81e-39: 127: 61.46
+	Hs
		657018 S10A1_HUMAN (1-94): 1.23e-38: 125: 100.00		S10A1_HUMAN (2-91): 3.93e-38: 124: 52.22
+	Hs
		657021 S10A1_HUMAN (1-94): 1.23e-38: 125: 100.00		S10A4_HUMAN (2-97): 3.37e-38: 124: 61.46
+	Hs
		407637 Q5T7Y6_HUMAN (1-94): 9.45e-43: 137: 100.00		S100B_HUMAN (4-92): 9.17e-33: 111: 44.94
+	Hs
		657024 S10A1_HUMAN (1-94): 1.23e-38: 125: 100.00		S10A3_HUMAN (2-98): 2.61e-36: 120: 43.30
+	Mm
		941878 S10A1_MOUSE (1-94): 8.83e-38: 123: 92.55		S10A1_MOUSE (2-91): 2.65e-37: 122: 51.11
+	Hs
		731754 S10AB_HUMAN (2-92): 1.28e-36: 121: 41.76		S10AB_HUMAN (2-97): 2.19e-37: 123: 29.90
+	Hs
		657019 S10A1_HUMAN (1-94): 1.23e-38: 125: 100.00		S100P_HUMAN (4-92): 1.21e-35: 118: 42.70
+	Hs
		657041 S10A1_HUMAN (1-94): 1.23e-38: 125: 100.00		S100Z_HUMAN (2-91): 3.93e-34: 114: 43.33
+	Hs
		407580 S10A1_HUMAN (1-94): 1.23e-38: 125: 100.00		S100B_HUMAN (4-92): 9.17e-33: 111: 44.94
+	Hs
		754563 S10AA_HUMAN (1-91): 9.1e-34: 113: 48.35		S10A3_HUMAN (2-98): 2.61e-36: 120: 43.30
+	Hs
		754587 S100Z_HUMAN (1-93): 1.03e-33: 113: 58.07		S10A3_HUMAN (2-98): 2.61e-36: 120: 43.30
+	Hs
		407589 S10AB_HUMAN (2-92): 1.28e-36: 121: 41.76		S100B_HUMAN (4-92): 9.17e-33: 111: 44.94
+	Hs
		682561 S100Z_HUMAN (1-93): 1.03e-33: 113: 58.07		S100P_HUMAN (4-92): 1.21e-35: 118: 42.70
+	Hs
		954979 S100Z_HUMAN (1-93): 1.03e-33: 113: 58.07		S10AA_HUMAN (2-91): 2.63e-33: 112: 36.67
+	Hs
		1204007 HORN_HUMAN (1-88): 3.8e-32: 119: 35.23		FILA2_HUMAN (4-91): 2.43e-27: 105: 32.96
+	Hs
		407671 S100Z_HUMAN (1-93): 1.03e-33: 113: 58.07		S100B_HUMAN (4-92): 9.17e-33: 111: 44.94