HitPredict

Interactor 1: S10A4 (P07091)
Protein S100-A4 (Metastasin) (Metastatic cell protein) (PEL98) (Placental calcium-binding protein) (Protein 18A2) (Protein Mts1) (S100 calcium-binding protein A4)
Gene: S100a4

Interactor 2: S10A1 (P56565)
Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)
Gene: S100a1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.756

Property	Details
Experiments	10869553
Identification Methods	ion exchange chromatography, classical fluorescence spectroscopy, two hybrid, mass spectrometry studies of complexes
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	EF-hand_1~S_100, S_100~S_100
Common GO terms	GO:0005509 - calcium ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 101 Mm			1 94
+	Hs
		1214472 Q5T7Y6_HUMAN (1-90): 3.67e-40: 131: 52.22		Q5T7Y6_HUMAN (1-94): 2.43e-42: 136: 92.55
+	Hs
		657021 S10A4_HUMAN (1-101): 2.58e-39: 128: 93.07		S10A1_HUMAN (1-94): 2.59e-38: 124: 92.55
+	Hs
		657018 S10A1_HUMAN (1-90): 2.16e-37: 122: 52.22		S10A1_HUMAN (1-94): 2.59e-38: 124: 92.55
+	Hs
		682510 Q5T7Y6_HUMAN (1-90): 3.67e-40: 131: 52.22		S100P_HUMAN (3-90): 1.77e-33: 112: 54.55
+	Hs
		731754 S10AB_HUMAN (2-97): 2.46e-37: 123: 28.87		S10AB_HUMAN (2-92): 1.98e-36: 120: 40.66
+	Mm
		941878 S10A1_MOUSE (1-90): 1.46e-36: 120: 48.89		S10A1_MOUSE (1-94): 1.48e-37: 123: 100.00
+	Mm
		450157 S10A4_MOUSE (1-101): 3.55e-40: 129: 100.00		S10A4_MOUSE (1-90): 6.1e-33: 111: 48.89
+	Hs
		686779 S10A4_HUMAN (1-101): 2.58e-39: 128: 93.07		S10A4_HUMAN (1-90): 9.67e-33: 111: 47.78
+	Hs
		686780 S10A4_HUMAN (1-101): 2.58e-39: 128: 93.07		S10A2_HUMAN (1-90): 4.89e-32: 109: 51.11
+	Hs
		407637 Q5T7Y6_HUMAN (1-90): 3.67e-40: 131: 52.22		S100B_HUMAN (3-90): 2.95e-30: 104: 57.96
+	Hs
		657019 S10A1_HUMAN (1-90): 2.16e-37: 122: 52.22		S100P_HUMAN (3-90): 1.77e-33: 112: 54.55
+	Hs
		657041 S10A1_HUMAN (1-90): 2.16e-37: 122: 52.22		S100Z_HUMAN (1-92): 1.36e-33: 112: 57.61
+	Hs
		407583 S10A4_HUMAN (1-101): 2.58e-39: 128: 93.07		S100B_HUMAN (3-90): 2.95e-30: 104: 57.96
+	Hs
		657022 S10A1_HUMAN (1-90): 2.16e-37: 122: 52.22		S10A2_HUMAN (1-90): 4.89e-32: 109: 51.11
+	Hs
		657024 S10A1_HUMAN (1-90): 2.16e-37: 122: 52.22		S10A3_HUMAN (1-90): 9.61e-31: 106: 41.11
+	Hs
		1204007 HORN_HUMAN (1-96): 5.38e-33: 121: 25.74		FILA2_HUMAN (3-93): 7.93e-28: 106: 37.36
+	Hs
		407589 S10AB_HUMAN (2-97): 2.46e-37: 123: 28.87		S100B_HUMAN (3-90): 2.95e-30: 104: 57.96
+	Hs
		407580 S10A1_HUMAN (1-90): 2.16e-37: 122: 52.22		S100B_HUMAN (3-90): 2.95e-30: 104: 57.96
+	Hs
		445129 S10A4_HUMAN (1-101): 2.58e-39: 128: 93.07		S10A6_HUMAN (1-90): 3.6e-27: 96.4: 41.11