HitPredict

Interactor 1: S10A1 (P23297)
Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)
Gene: S100A1

Interactor 2: RAGE (Q15109)
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Gene: AGER

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	17726019
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C2-set_2~S_100, Ig_3~S_100
Common GO terms	GO:0005576 - extracellular region GO:0005634 - nucleus GO:0044548 - S100 protein binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 94 Hs			1 404
+	Rn
		412916 S100B_RAT (3-93): 9.01e-30: 102: 58.24		RAGE_RAT (1-404): 1.88e-76: 244: 75.99
+	Hs
		682489 S100P_HUMAN (3-92): 7.78e-34: 113: 54.44		RAGE_HUMAN (1-404): 1.78e-71: 231: 100.00
+	Hs
		686812 S10A4_HUMAN (1-90): 7.75e-33: 111: 51.11		RAGE_HUMAN (1-404): 1.78e-71: 231: 100.00
+	Hs
		407626 S100B_HUMAN (3-93): 2.67e-30: 104: 58.24		RAGE_HUMAN (1-404): 1.78e-71: 231: 100.00
+	Hs
		1010255 S10AC_HUMAN (3-93): 2.19e-29: 102: 37.36		RAGE_HUMAN (1-404): 1.78e-71: 231: 100.00
+	Hs
		845574 S10AA_HUMAN (1-91): 9.1e-34: 113: 48.35		MUC18_HUMAN (22-301): 1.39e-58: 203: 24.92
+	Hs
		682563 S100P_HUMAN (3-92): 7.78e-34: 113: 54.44		PXDN_HUMAN (172-403): 5.1e-25: 109: 13.42
+	Hs
		686847 S10A4_HUMAN (1-90): 7.75e-33: 111: 51.11		PXDN_HUMAN (172-403): 5.1e-25: 109: 13.42
+	Hs
		706244 S10A2_HUMAN (1-90): 4.94e-32: 109: 52.22		PXDN_HUMAN (172-403): 5.1e-25: 109: 13.42