HitPredict

Interactor 1: S100P (P25815)
Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P)
Gene: S100P

Interactor 2: RAGE (Q15109)
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Gene: AGER

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	14617629, 16061848
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2-set_2~S_100, Ig_3~S_100
Common GO terms	GO:0005576 - extracellular region GO:0005634 - nucleus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 95 Hs			1 404
+	Rn
		412916 S100B_RAT (1-92): 1.49e-31: 107: 48.91		RAGE_RAT (1-404): 1.88e-76: 244: 75.99
+	Hs
		657034 S10A1_HUMAN (2-93): 3.46e-36: 119: 53.26		RAGE_HUMAN (1-404): 1.78e-71: 231: 100.00
+	Hs
		686812 S10A4_HUMAN (3-95): 6.78e-34: 113: 41.94		RAGE_HUMAN (1-404): 1.78e-71: 231: 100.00
+	Hs
		407626 S100B_HUMAN (1-92): 4.66e-32: 109: 50.00		RAGE_HUMAN (1-404): 1.78e-71: 231: 100.00
+	Hs
		1010255 S10AC_HUMAN (1-92): 7.45e-31: 106: 44.57		RAGE_HUMAN (1-404): 1.78e-71: 231: 100.00
+	Hs
		845574 S10AA_HUMAN (2-89): 6.19e-31: 106: 44.32		MUC18_HUMAN (22-301): 1.39e-58: 203: 24.92
+	Hs
		682563 S100P_HUMAN (1-95): 8.19e-37: 121: 100.00		PXDN_HUMAN (172-403): 5.1e-25: 109: 13.42
+	Hs
		686847 S10A4_HUMAN (3-95): 6.78e-34: 113: 41.94		PXDN_HUMAN (172-403): 5.1e-25: 109: 13.42
+	Hs
		706244 S10A2_HUMAN (2-95): 1.83e-32: 110: 40.43		PXDN_HUMAN (172-403): 5.1e-25: 109: 13.42