HitPredict

Interactor 1: DUS1 (P28562)
Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100)
Gene: DUSP1

Interactor 2: MK14 (Q16539)
Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
Gene: MAPK14

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.967

The method score is based on:

Property Details
Experiments 27880917, 27432908, 28675297, 11278799, 11359773, 20936779, 20347885
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach, phosphatase assay
Interaction Type physical association, direct interaction, dephosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains DSPc~Pkinase, Pkinase~Rhodanese
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 367
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024