HitPredict

Interactor 1: RBL1 (P28749)
Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)
Gene: RBL1

Interactor 2: E2F4 (Q16254)
Transcription factor E2F4 (E2F-4)
Gene: E2F4

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.970

Property	Details
Experiments	9501179, 12401786, 9233764, 9343408, 12150994, 9858615, 17671431, 8657117, 7958925, 7958924, 9724731
Identification Methods	affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	E2F_CC-MB~Rb_C
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0007049 - cell cycle GO:1990841 - promoter-specific chromatin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1068 Hs			1 413
+	Mm
		1145491 RBL1_MOUSE (1-1068): 0: 1473: 90.45		E2F4_MOUSE (1-413): 4.62e-177: 501: 92.03
+	Hs
		997125 RBL2_HUMAN (19-1068): 0: 1356: 50.32		E2F4_HUMAN (1-413): 0: 528: 100.00
+	Hs
		660138 RBL1_HUMAN (1-1068): 0: 1528: 100.00		E2F2_HUMAN (4-252): 2.04e-83: 263: 43.83
+	Hs
		660118 RBL1_HUMAN (1-1068): 0: 1528: 100.00		E2F1_HUMAN (10-278): 8.99e-81: 257: 35.29
+	Hs
		135214 RBL1_HUMAN (1-1068): 0: 1528: 100.00		E2F3_HUMAN (5-289): 3.49e-79: 253: 36.93
+	Hs
		660143 RBL1_HUMAN (1-1068): 0: 1528: 100.00		E2F5_HUMAN (304-412): 2.39e-35: 134: 39.34
+	Hs
		963598 RBL2_HUMAN (19-1068): 0: 1356: 50.32		E2F1_HUMAN (10-278): 8.99e-81: 257: 35.29
+	Hs
		997123 RBL2_HUMAN (19-1068): 0: 1356: 50.32		E2F5_HUMAN (304-412): 2.39e-35: 134: 39.34
+	Hs
		414299 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		E2F4_HUMAN (1-413): 0: 528: 100.00
+	Mm
		527164 RB_MOUSE (718-1046): 4.9e-86: 300: 28.32		E2F4_MOUSE (1-413): 4.62e-177: 501: 92.03
+	Hs
		414284 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		E2F2_HUMAN (4-252): 2.04e-83: 263: 43.83
+	Mm
		527140 RB_MOUSE (718-1046): 4.9e-86: 300: 28.32		E2F2_MOUSE (4-244): 2.59e-82: 260: 43.09
+	Hs
		414250 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		E2F1_HUMAN (10-278): 8.99e-81: 257: 35.29
+	Hs
		135199 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		E2F3_HUMAN (5-289): 3.49e-79: 253: 36.93
+	Mm
		192503 RB_MOUSE (718-1046): 4.9e-86: 300: 28.32		E2F3_MOUSE (5-255): 3.63e-78: 250: 37.55
+	Hs
		265585 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		E2F6_HUMAN (17-244): 1.21e-72: 230: 34.35
+	Mm
		527156 RB_MOUSE (718-1046): 4.9e-86: 300: 28.32		E2F1_MOUSE (10-278): 3.12e-69: 226: 34.19
+	Rn
		140344 RB_RAT (735-1046): 1.14e-84: 296: 28.27		E2F1_RAT (10-278): 2.31e-68: 224: 33.95
+	Dm
		284513 RBF_DROME (779-1028): 7.56e-72: 258: 31.47		E2F2_DROME (5-192): 8.58e-52: 179: 31.91
+	Hs
		414295 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		E2F5_HUMAN (304-412): 2.39e-35: 134: 39.34