HitPredict

Interactor 1: RBL1 (P28749)
Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)
Gene: RBL1

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10490602
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:1990841 - promoter-specific chromatin binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1068 Hs			1 488
+	Hs
		660131 RBL1_HUMAN (1-1068): 0: 1528: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177207 RBL1_HUMAN (1-1068): 0: 1528: 100.00		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Mm
		140283 RBL2_MOUSE (19-1068): 0: 1371: 49.28		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Rn
		223062 RBL2_RAT (19-1068): 0: 1365: 49.46		HDAC1_RAT (1-443): 0: 645: 90.29
+	Hs
		997110 RBL2_HUMAN (19-1068): 0: 1356: 50.32		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		414344 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		140218 RB_MOUSE (718-1046): 4.9e-86: 300: 28.32		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		414272 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Dm
		1097886 RBF_DROME (779-1028): 7.56e-72: 258: 31.47		HDAC1_DROME (5-472): 0: 653: 77.92
+	Hs
		177169 RB_HUMAN (735-1046): 2.21e-85: 298: 28.88		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Ce
		106297 LIN35_CAEEL (752-994): 1.23e-47: 186: 25.41		HDA1_CAEEL (7-456): 0: 595: 64.02
+	Dm
		1276537 Q9VF04_DROME (772-981): 4.21e-15: 82.2: 23.66		HDAC1_DROME (5-472): 0: 653: 77.92