HitPredict

Interactor 1: GRN (P28799)
Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]
Gene: GRN

Interactor 2: CDK9 (P50750)
Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)
Gene: CDK9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	12588988, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 372
+	Hs
		625139 GRN_HUMAN (1-593): 0: 726: 100.00		CDK2_HUMAN (16-321): 4.46e-136: 391: 38.76
+	Hs
		647476 GRN_HUMAN (1-593): 0: 726: 100.00		MK03_HUMAN (1-359): 1.92e-131: 382: 30.36
+	Hs
		658799 GRN_HUMAN (1-593): 0: 726: 100.00		MK01_HUMAN (5-359): 1.35e-131: 382: 30.99
+	Os
		637313 ORYA_ORYSJ (128-188): 3.75e-15: 80.1: 32.35		MPK3_ORYSJ (3-360): 1.51e-132: 385: 29.61