Protein: ORC2
Origin recognition complex subunit 2 (Origin recognition complex 71 kDa subunit)

Gene: ORC2
Organism: Saccharomyces cerevisiae S288C
Interactions: 65
UniProt ID: P32833

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

745656

ORC5
Origin recognition complex subunit 5

14

4

Small-scale

0.982

High

745663

ORC1
Origin recognition complex subunit 1

14

13

Small-scale

0.980

High

745665

ORC4
Origin recognition complex subunit 4

11

13

Small-scale

0.975

High

479258

CDC6
Cell division control protein 6

8

14

Small-scale

0.963

High

745664

ORC3
Origin recognition complex subunit 3

14

0

Small-scale

0.933

High

664426

MCM3
DNA replication licensing factor MCM3

2

9

Small-scale

0.778

High

745639

ORC2
Origin recognition complex subunit 2

2

4

Small-scale

0.754

High

745646

ORC6
Origin recognition complex subunit 6

12

0

Small-scale

0.727

High

364431

CDK1
Cyclin-dependent kinase 1

5

6

Small-scale

0.718

High

745643

PCH2
Pachytene checkpoint protein 2

1

0

Small-scale

0.687

High

712960

MCM2
DNA replication licensing factor MCM2

3

9

Small-scale

0.670

High

734251

DBF4
DDK kinase regulatory subunit DBF4

3

0

Small-scale

0.632

High

745675

HAT1
Histone acetyltransferase type B catalytic subunit

3

0

Small-scale

0.622

High

713252

MCM5
Minichromosome maintenance protein 5

2

8

Small-scale

0.602

High

745644

MCM7
DNA replication licensing factor MCM7

2

8

Small-scale

0.602

High

381464

H2B2
Histone H2B.2

2

5

High-throughput

0.601

High

419668

H2A2
Histone H2A.2

2

1

High-throughput

0.601

High

745655

CDT1
Cell division cycle protein CDT1

2

0

Small-scale

0.598

High

718933

CGS5
S-phase entry cyclin-5

2

4

Small-scale

0.595

High

735368

MCM10
Minichromosome maintenance protein 10

2

3

Small-scale

0.595

High

381982

H4
Histone H4

2

2

High-throughput

0.588

High

745650

FKH1
Fork head protein homolog 1

2

5

Small-scale

0.584

High

745667

CDC14
Tyrosine-protein phosphatase CDC14

1

1

Small-scale

0.573

High

381037

H2B1
Histone H2B.1

2

5

High-throughput

0.571

High

745668

SPP1
COMPASS component SPP1

1

1

Small-scale

0.552

High

526250

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.552

High

544265

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.552

High

745673

CLF1
Pre-mRNA-splicing factor CLF1

1

0

Small-scale

0.549

High

745651

MAD1
Spindle assembly checkpoint component MAD1

1

3

Small-scale

0.541

High

745660

PESC
Pescadillo homolog

1

0

Small-scale

0.537

High

649540

CHL1
ATP-dependent DNA helicase CHL1

1

0

Small-scale

0.529

High

745649

CSM2
Chromosome segregation in meiosis protein 2

1

0

Small-scale

0.529

High

745659

THG1
tRNA(His) guanylyltransferase

1

0

Small-scale

0.529

High

745674

PSY3
Platinum sensitivity protein 3

1

0

Small-scale

0.529

High

550640

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.518

High

662082

MPIP
M-phase inducer phosphatase

1

0

Small-scale

0.518

High

745669

HMO1
High mobility group protein 1

1

3

High-throughput

0.515

High

403423

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.513

High

721358

MCM4
DNA replication licensing factor MCM4

1

10

Small-scale

0.501

High

740559

IME2
Meiosis induction protein kinase IME2/SME1

1

6

Small-scale

0.501

High

745657

MCM6
DNA replication licensing factor MCM6

1

9

Small-scale

0.501

High

745671

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.493

High

440921

CDC7
Cell division control protein 7

1

7

Small-scale

0.481

High

745652

FKH2
Fork head protein homolog 2

1

5

Small-scale

0.479

High

745666

H3
Histone H3

1

7

Small-scale

0.479

High

745647

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

0

Small-scale

0.460

High

745658

SLD3
DNA replication regulator SLD3

1

0

Small-scale

0.460

High

745661

IPI3
Pre-rRNA-processing protein IPI3

1

0

Small-scale

0.460

High

745670

NOC3
Nucleolar complex-associated protein 3

1

0

Small-scale

0.460

High

639860

SIR1
Regulatory protein SIR1

1

0

Small-scale

0.458

High

706598

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

745640

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

745641

BMH2
Protein BMH2

1

0

Small-scale

0.458

High

745642

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

745645

NU170
Nucleoporin NUP170

1

0

High-throughput

0.458

High

745653

SUM1
Suppressor of mar1-1 protein

1

0

Small-scale

0.458

High

745662

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

523442

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

741241

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

745648

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

745676

CAF1A
Chromatin assembly factor 1 subunit A

1

1

High-throughput

0.445

High

745672

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.249

Low

432528

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.232

Low

745654

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025