Protein: ORC2
Origin recognition complex subunit 2

Gene: ORC2
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q13416

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0000792 - heterochromatin
GO:0000808 - origin recognition complex
GO:0000939 - inner kinetochore

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1104374

ORC3
Origin recognition complex subunit 3

13

4

Small-scale

0.982

High

230900

ORC5
Origin recognition complex subunit 5

12

18

Small-scale

0.982

High

1104303

ORC1
Origin recognition complex subunit 1

12

13

Small-scale

0.981

High

231474

ORC4
Origin recognition complex subunit 4

12

13

Small-scale

0.979

High

1104364

CDC6
Cell division control protein 6 homolog

2

12

Small-scale

0.821

High

1104339

ORC2
Origin recognition complex subunit 2

2

3

Small-scale

0.757

High

1104382

ORC6
Origin recognition complex subunit 6

8

2

Small-scale

0.751

High

1104376

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

5

0

Small-scale

0.678

High

899879

FXR1
RNA-binding protein FXR1

4

0

Small-scale

0.664

High

1104343

TERF2
Telomeric repeat-binding factor 2

2

1

Small-scale

0.653

High

1104353

MCM10
Protein MCM10 homolog

2

3

Small-scale

0.650

High

558102

XRCC6
X-ray repair cross-complementing protein 6

3

1

Small-scale

0.640

High

1104356

SIR2
NAD-dependent protein deacetylase sirtuin-2

3

0

High-throughput

0.638

High

1104369

STN1
CST complex subunit STN1

3

0

High-throughput

0.638

High

888034

MCM2
DNA replication licensing factor MCM2

2

9

Small-scale

0.636

High

1104363

CDC5L
Cell division cycle 5-like protein

2

1

High-throughput

0.629

High

667826

CDK2
Cyclin-dependent kinase 2

2

6

Small-scale

0.619

High

1104367

CDT1
DNA replication factor Cdt1

2

1

Small-scale

0.611

High

629117

CCNA2
Cyclin-A2

2

3

Small-scale

0.611

High

1104360

RPGR
X-linked retinitis pigmentosa GTPase regulator

2

0

High-throughput

0.602

High

559339

XRCC5
X-ray repair cross-complementing protein 5

2

1

Small-scale

0.584

High

799073

BRCA1
Breast cancer type 1 susceptibility protein

2

1

Small-scale

0.584

High

998284

H31
Histone H3.1

2

4

High-throughput

0.584

High

943475

DSCR6
Protein ripply3

2

0

High-throughput

0.580

High

1104371

RAD18
E3 ubiquitin-protein ligase RAD18

2

0

High-throughput

0.580

High

755702

MCM4
DNA replication licensing factor MCM4

2

8

Small-scale

0.576

High

601658

HMGA1
High mobility group protein HMG-I/HMG-Y

2

0

Small-scale

0.576

High

979605

H4
Histone H4

2

1

High-throughput

0.563

High

588615

RFA2
Replication protein A 32 kDa subunit

2

0

Small-scale

0.561

High

695372

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

Small-scale

0.561

High

1104350

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

1

Small-scale

0.561

High

1061577

FOXM1
Forkhead box protein M1

1

3

High-throughput

0.554

High

133111

FOXE1
Forkhead box protein E1

1

5

High-throughput

0.536

High

221936

FOXS1
Forkhead box protein S1

1

4

High-throughput

0.536

High

937624

FOXG1
Forkhead box protein G1

1

4

High-throughput

0.536

High

1091273

FOXL1
Forkhead box protein L1

1

3

High-throughput

0.536

High

1104348

H2B2E
Histone H2B type 2-E

1

3

High-throughput

0.536

High

1104365

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.536

High

1104375

DBF4A
Protein DBF4 homolog A

1

0

Small-scale

0.529

High

1067278

EP300
Histone acetyltransferase p300

1

0

Small-scale

0.527

High

74480

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.513

High

407621

S100B
Protein S100-B

1

0

High-throughput

0.513

High

913484

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.513

High

1104340

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1104344

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

1104366

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.513

High

1104370

PAR6A
Partitioning defective 6 homolog alpha

1

0

High-throughput

0.513

High

1104383

RBM8A
RNA-binding protein 8A

1

0

High-throughput

0.513

High

332001

KAT7
Histone acetyltransferase KAT7

1

1

Small-scale

0.501

High

669891

MCM3
DNA replication licensing factor MCM3

1

10

Small-scale

0.500

High

755904

MCM5
DNA replication licensing factor MCM5

1

9

Small-scale

0.481

High

756177

MCM7
DNA replication licensing factor MCM7

1

8

Small-scale

0.481

High

1104341

MCM6
DNA replication licensing factor MCM6

1

9

Small-scale

0.481

High

1089383

ILF2
Interleukin enhancer-binding factor 2

1

0

Small-scale

0.479

High

302506

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

Small-scale

0.479

High

355515

NSD2
Histone-lysine N-methyltransferase NSD2

1

1

Small-scale

0.479

High

520014

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

853248

CBX5
Chromobox protein homolog 5

1

2

Small-scale

0.479

High

928438

TERF1
Telomeric repeat-binding factor 1

1

1

Small-scale

0.479

High

980743

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

1004521

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1016831

H33
Histone H3.3

1

4

High-throughput

0.479

High

1097272

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.479

High

1104345

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1104359

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1104380

MCM8
DNA helicase MCM8

1

11

Small-scale

0.479

High

281205

CDC45
Cell division control protein 45 homolog

1

0

Small-scale

0.460

High

129051

MEN1
Menin

1

0

High-throughput

0.458

High

157325

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

223007

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

315553

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

340881

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

0

High-throughput

0.458

High

385713

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

646833

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

684227

DDX6
Probable ATP-dependent RNA helicase DDX6

1

0

High-throughput

0.458

High

768107

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

879052

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

995575

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

1029822

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

1104342

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1104352

ASXL2
Putative Polycomb group protein ASXL2

1

0

High-throughput

0.458

High

1104354

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1104355

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1104357

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1104358

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

1104361

CIC
Protein capicua homolog

1

0

High-throughput

0.458

High

1104373

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

Small-scale

0.458

High

1104377

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1104379

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1104381

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1007636

CCNA1
Cyclin-A1

1

3

Small-scale

0.445

High

397950

ANGI
Angiogenin

1

0

High-throughput

0.426

High

697104

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

Small-scale

0.426

High

1104347

H31T
Histone H3.1t

1

4

High-throughput

0.408

High

1104378

CTNA3
Catenin alpha-3

2

0

High-throughput

0.316

High

249288

BRNP1
BMP/retinoic acid-inducible neural-specific protein 1

1

0

High-throughput

0.279

Low

922380

CRBA4
Beta-crystallin A4

1

0

High-throughput

0.279

Low

1104346

CART

1

0

High-throughput

0.279

Low

1104372

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

1

0

High-throughput

0.279

Low

562848

CCL2
C-C motif chemokine 2

1

0

Small-scale

0.249

Low

1104349

OBI1
ORC ubiquitin ligase 1

1

0

Small-scale

0.249

Low

1104351

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1104368

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1104362

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025