HitPredict

Interactor 1: PTN4 (P29074)
Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)
Gene: PTPN4

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.850

Property	Details
Experiments	23666597, 21988832
Identification Methods	two hybrid, enzymatic study, pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PDZ~SH3_2, SH2~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008092 - cytoskeletal protein binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 926 Hs			1 304
+	Hs
		663966 PTN4_HUMAN (1-926): 0: 949: 100.00		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		663972 PTN4_HUMAN (1-926): 0: 949: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		557617 PTN4_HUMAN (1-926): 0: 949: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		802784 E41L3_HUMAN (21-682): 1.53e-132: 427: 27.22		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		299235 FARP2_HUMAN (8-507): 5.08e-133: 427: 34.40		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		299283 FARP2_HUMAN (8-507): 5.08e-133: 427: 34.40		Q96D37_HUMAN (11-189): 5.17e-47: 170: 28.21
+	Hs
		548649 PTN6_HUMAN (546-913): 1.07e-134: 417: 32.46		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		576998 PTPRA_HUMAN (639-912): 7.66e-96: 321: 33.45		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Ce
		104061 G5EBP4_CAEEL (10-509): 1.04e-129: 434: 28.30		SEM5_CAEEL (135-291): 6.58e-25: 101: 14.83
+	Ce
		106817 G5EEG8_CAEEL (10-509): 1.32e-129: 434: 28.30		SEM5_CAEEL (135-291): 6.58e-25: 101: 14.83
+	Hs
		580938 PTN6_HUMAN (546-913): 1.07e-134: 417: 32.46		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		562628 PTN6_HUMAN (546-913): 1.07e-134: 417: 32.46		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		665853 PTN6_HUMAN (546-913): 1.07e-134: 417: 32.46		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Mm
		250716 E41L2_MOUSE (18-510): 1.54e-124: 403: 33.40		PLCG2_MOUSE (11-301): 1.34e-25: 108: 16.40
+	Mm
		574006 PTPRA_MOUSE (639-912): 1.11e-95: 321: 33.45		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		577009 PTPRA_HUMAN (639-912): 7.66e-96: 321: 33.45		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		208991 PTPRA_HUMAN (639-912): 7.66e-96: 321: 33.45		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		146925 PTPRT_HUMAN (649-914): 3.08e-55: 210: 28.21		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67