HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.998

The method score is based on:

Property Details
Experiments 11370743, 24189400, 8810340, 24430869, 9032244, 12149229, 16371368, 7559490, 28690151, 9797459, 26551075, 15888547, 9019162, 7516467, 8561895, 9020193, 8939605, 8235613, 8491186, 8647288 and 69 others

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Identification Methods affinity chromatography technology, unspecified method, pull down, anti tag coimmunoprecipitation, bimolecular fluorescence complementation, tandem affinity purification, anti bait coimmunoprecipitation, nuclear magnetic resonance, isothermal titration calorimetry, surface plasmon resonance and 2 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains SH2~SH2, SH2~SH3_1
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005154 - epidermal growth factor receptor binding
GO:0005168 - neurotrophin TRKA receptor binding
GO:0005829 - cytosol
and 6 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 583
Hs

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Last updated: 15 Jul 2024