HitPredict

Interactor 1: IL12A (P29459)
Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (NK cell stimulatory factor chain 1) (NKSF1)
Gene: IL12A

Interactor 2: IL27B (Q14213)
Interleukin-27 subunit beta (IL-27 subunit beta) (IL-27B) (Epstein-Barr virus-induced gene 3 protein) (EBV-induced gene 3 protein)
Gene: EBI3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	18033300, 9342359
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005125 - cytokine activity GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005788 - endoplasmic reticulum lumen GO:0032729 - positive regulation of type II interferon production
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 219 Hs			1 229
+	Hs
		667323 IL12A_HUMAN (1-219): 1.83e-123: 350: 100.00		IL12B_HUMAN (33-218): 1.26e-39: 140: 21.85
+	Mm
		192436 IL12A_MOUSE (1-219): 8.51e-115: 328: 58.90		IL27B_MOUSE (1-229): 9.97e-42: 143: 60.26
+	Hs
		667340 IL12A_HUMAN (1-219): 1.83e-123: 350: 100.00		I12R2_HUMAN (16-219): 8.13e-27: 109: 19.52